Publications by authors named "Akylbek Tussupkaliyev"

Article Synopsis
  • About 26% of pregnancies end in miscarriage, with many cases remaining unexplained despite known causes like chromosomal abnormalities and uterine issues.
  • A review of 27 studies involving over 134,000 patients examined various biochemical factors potentially linked to early pregnancy loss.
  • Current research suggests there is no definitive biochemical marker for predicting first-trimester pregnancy losses, highlighting the need for combined indicators or new assessment models like α-fetoprotein in vaginal blood.
View Article and Find Full Text PDF

The incidence of ectopic pregnancy (EP) has increased in recent years, owing to causes such as pelvic inflammatory diseases and assisted reproductive technologies (ART). The present study reported a case of a 33-year-old nulliparous woman with a history of previous ectopic pregnancies, who underwent pelvic ultrasound in August 2022, which revealed a double EP including a cervical pregnancy and a tubal stump pregnancy. Despite known risk factors and elevated beta-human chorionic gonadotropin (β-hCG) levels, a conservative approach, utilizing multiple doses of systemic methotrexate (MTX) injections, was employed to preserve fertility at the Regional Perinatal Center in Aktobe, Kazakhstan.

View Article and Find Full Text PDF

The rationale and importance of folic acid supplementation during pregnancy for fetal congenital defect prevention are accepted worldwide. Moreover, a sufficient plasma concentration of folates can reduce the incidence of spontaneous abortions, and support the normal expansion of placental blood vessels, ensuring physiological placental blood flow, thus promoting appropriate fetal growth and development. Furthermore, there is emerging evidence that long-term supplementation with folic acid can effectively prevent preeclampsia.

View Article and Find Full Text PDF

Objective:  To assess homocysteine (Hcy) levels in the three trimesters of pregnancy in women with fetal growth restriction (FGR) and to evaluate the role of Hcy as a possible predictor of FGR.

Methods:  A total of 315 singleton pregnant women were included in the present prospective cohort study and were monitored since the 1 trimester of pregnancy before delivery. Newborns were monitored for the first 7 days of life.

View Article and Find Full Text PDF

Background: Various types of normal and cancer cells undergo senescence in response to carboplatin and paclitaxel, which are considered the gold standard treatments in ovarian cancer management. Surprisingly, the effect of these drugs on ovarian cancer cell senescence remained unknown.

Methods: The experiments were conducted on primary high-grade serous ovarian cancer cells.

View Article and Find Full Text PDF

To assess homocysteine (Hcy) concentration in women with preeclampsia (PE). Hcy concentrations were detected by ELISA in 305 pregnancies. Hcy concentration in patients with PE was 16.

View Article and Find Full Text PDF

Research purpose was to put together the available pieces of present scientific data and to close the gap in the knowledge of Hcy levels in pregnancy and its association with some pregnancy complications. Scientific data were taken from research papers published between January 1990 and December 2017, and found on the Internet (PubMed, ClinicalKey and Embase databases) by the following tags entered in English, Russian, French and German languages: pregnancy, homocysteine, pregnancy complications, pregnancy loss, preeclampsia, intrauterine growth restriction, and placental abruption. The review showed that Hcy levels range in uncomplicated pregnancy.

View Article and Find Full Text PDF