Publications by authors named "Akula Ruchitha Sai"
Antiparkinson potential of khellin on rotenone-induced Parkinson's disease in a zebrafish model: targeting MAO, inflammatory, and oxidative stress markers with molecular docking, MD simulations, and histopathology evidence.
A Hemanth Babu D S N B K Prasanth Deepak A Yaraguppi Siva Prasad Panda Sheikh F Ahmad Akula Ruchitha Sai
Comp Biochem Physiol C Toxicol Pharmacol
October 2024
Article Synopsis
- - The study investigated the potential of khellin (KL) to counteract the effects of Parkinson's disease (PD) induced by rotenone in zebrafish, using various analyses including drug assessments, molecular docking, and dynamics studies which indicated strong binding affinity of KL to monoamine oxidase B (MAO-B).
- - KL demonstrated significant antioxidant properties in vitro, suggesting it can help maintain redox balance, and further in vivo analysis revealed that KL treatment improved locomotor activity and social interactions in zebrafish models of PD while also reducing various oxidative stress markers.
- - Histopathological examinations showed that KL treatment effectively alleviated brain abnormalities associated with PD, highlighting its potential therapeutic benefits for PD symptoms.