Distinct Network Morphologies from In Situ Polymerization of Microtubules in Giant Polymer-Lipid Hybrid Vesicles.

Creating artificial cells with a dynamic cytoskeleton, akin to those in living cells, is a major goal in bottom-up synthetic biology. In this study, we demonstrate the in situ polymerization of microtubules encapsulated in giant polymer-lipid hybrid vesicles (GHVs) composed of 1,2-dioleoyl-sn-glycero-3-phosphocholine and an amphiphilic block copolymer. The block copolymer is comprised of poly(cholesteryl methacrylate-co-butyl methacrylate) as the hydrophobic block and either poly(6-O-methacryloyl-D-galactopyranose) or poly(carboxyethyl acrylate) as the hydrophilic extension.

Sustainable and scalable one-pot synthesis of diaryliodonium salts.

Two one-pot routes from iodoarenes to diaryliodonium triflates have been developed in the sustainable solvent ethyl acetate. The first method yields the recently reported aryl(dimethylisoxazolyl)iodonium triflates, circumventing the need for stepwise synthesis of this chemoselective arylating reagent. The second method gives other types of diaryliodonium salts, and the scalability of the protocols was exhibited with two >45 mmol scale-ups with impressively low -factors.

DHUpredET: A Comparative Computational Approach for Identification of Dihydrouridine Modification Sites in RNA Sequence.

Laboratory-based detection of D sites is laborious and expensive. In this study, we developed effective machine learning models employing efficient feature encoding methods to identify D sites. Initially, we explored various state-of-the-art feature encoding approaches and 30 machine learning techniques for each and selected the top eight models based on their independent testing and cross-validation outcomes.

Enhancing physio biochemical traits and yield of common buckwheat Fagopyrum esculentum with rice husk biochar and nano iron oxide under water stress.

Climate change is making droughts more frequent, which is a major problem for crop yield, especially for crops that are vulnerable to drought, such as common buckwheat (Fagopyrum esculentum). Drought stress affects negatively on physiological and biochemical processes of plants, leading to reduced yields. This study addresses the knowledge gap regarding effective strategies to mitigate drought-induced damage and enhance productivity in buckwheat.

In-Depth Analysis of Electron and Hole Transport Layers for Enhancing CaPI Solar Cell Efficiency through Advanced Numerical Simulation.

This study investigates lead-free calcium-phosphorus iodide (CaPI) perovskite solar cells with various electron transport layers (ETLs) like TiO and SnS and hole transport layers (HTLs) such as CuO, MoO, PHT, SbS, CuSbS, and GeSe. The ideal HTL, MoO, was chosen, and its performance was simulated by using the SCAPS-1D tool. Two device structures were analyzed: device-I (Al/FTO/TiO/CaPI/MoO/Ni) and device-II (Al/FTO/SnS/CaPI/MoO/Ni).

Enhancing nutritional value and quality of cookies through pumpkin peel and seed powder fortification.

Background: Recently, the pumpkin by-products such as peels and seeds become more and more interesting for confectionary sector, because of the nutritional and bioactive composition. The study was conducted to develop cookies and noodles using different pumpkin by-products (such as peels and seeds) powders in different concentrations and to evaluate the changes in quality characteristics. The powders were prepared from pumpkin seeds and peels.

Complete genome sequence of chicken anemia virus from a field outbreak in Bangladesh.

Chicken anemia virus (CAV) causes immunosuppression and increased mortality in chickens globally, including Bangladesh. This report provides the complete genome sequence of a CAV strain from a recent outbreak on a Bangladeshi layer farm, contributing to the limited availability of published data on the CAV genome in the country.

Aging in Bangladesh: A Wake-Up Call for Elderly Care Solutions.

Background And Aims: Bangladesh has been experiencing a rapid demographic shift from the younger population to older adults, with the older adults facing significant challenges due to the absence of residential and formal home care models. This perspective aimed to evaluate the status of residential and formal home care models and propose potential strategies to improve elderly care in Bangladesh.

Methods: This perspective utilized a narrative review approach to search existing literature on elderly care in Bangladesh on PubMed, Google Scholar, and Web of Science.

Assessing Contributory Factors of Diarrhea Among Under-Five Children in Bangladesh From 2006 to 2019 and Recent Increases: A Cross-Sectional Study.

Background And Aims: One-third of all child deaths in this country are caused by diarrhea. The burden of the disease appears to be increasing in recent years in Bangladesh. This study aimed to analyze the prevalence of diarrhea and identify the factors contributing to diarrheal diseases among children aged 0-5 years in Bangladesh from 2006 to 2019, to understand the recent increase in this serious health issue.

Investigation of Tilapia (Oreochromis niloticus) Mortality Events Targeting Tilapia Lake Virus Disease (TiLVD) in Bangladesh.

Background: Tilapia lake virus (TiLV) is an emerging threat to the global tilapia industry. In early 2017, FAO declared that Bangladesh was in a high-risk zone of TiLV disease (TiLVD) spread.

Objectives: Considering the current scenario, the present work was designed to investigate the occurrence of TiLV in cultured Nile tilapia (Oreochromis niloticus) causing TiLVD in Bangladesh.

Identifying health risk determinants and molecular targets in patients with idiopathic pulmonary fibrosis via combined differential and weighted gene co-expression analysis.

Introduction: Idiopathic pulmonary fibrosis (IPF) is a rare but debilitating lung disease characterized by excessive fibrotic tissue accumulation, primarily affecting individuals over 50 years of age. Early diagnosis is challenging, and without intervention, the prognosis remains poor. Understanding the molecular mechanisms underlying IPF pathogenesis is crucial for identifying diagnostic markers and therapeutic targets.

Multisystemic impact of autosomal dominant polycystic kidney disease: A case report highlighting renal, hepatic, and neurological involvement.

We present a case of a 64-year-old male with Autosomal Dominant Polycystic Kidney Disease (ADPKD), characterized by systemic involvement, including renal, hepatic, and neurological complications. The patient presented with persistent micturition difficulties, hematuria, and abdominal pain, compounded by hypertension and chronic obstructive pulmonary disease. Imaging revealed bilateral renal enlargement with hemorrhagic cysts, a kidney stone, and hepatic cysts causing hepatomegaly.

Evaluating the impacts of microplastics on agricultural soil physical, chemical properties, and toxic metal availability: An emerging concern for sustainable agriculture.

Microplastics (MPs) are an emerging environmental issue that might endanger the health of agricultural soil. Even though several research on the particular toxicity of MPs to species have been carried out, there is little information on MPs' impacts on soil physicochemical properties and heavy metals (HMs) availability of HMs contaminated and without contaminated soils. This study examined the changes in soil characteristics for both HMs contaminated and without contaminated soils by five distinct MPs, including Polyethylene (PE), Polyethylene terephthalate (PET), Polystyrene Foam (PS), Polyamide (PA), and a combination of these four types of MPs (Mixed MPs), at two different concentrations (0.

Exploring the dynamics of SARS-CoV-2 and HIV Co-infection: Mutation risks, therapeutic efficacy, and future variant prevention.

High mutation rates in SARS-CoV-2, particularly among immunocompromised patients living with HIV, continue to complicate the current COVID-19 pandemic. The threshold for severe COVID-19 and a greater risk of mortality have increased in many immunocompromised individuals due to a weakened immune system. Low CD4+ T-cell counts in people living with both HIV and COVID-19 lead to prolonged disease duration and, therefore, an increased likelihood of viral infection with SARS-CoV-2 mutations in such individuals.

Light-Triggered Protease-Mediated Release of Actin-Bound Cargo from Synthetic Cells.

Synthetic cells offer a versatile platform for addressing biomedical and environmental challenges, due to their modular design and capability to mimic cellular processes such as biosensing, intercellular communication, and metabolism. Constructing synthetic cells capable of stimuli-responsive secretion is vital for applications in targeted drug delivery and biosensor development. Previous attempts at engineering secretion for synthetic cells have been confined to non-specific cargo release via membrane pores, limiting the spatiotemporal precision and specificity necessary for selective secretion.

Complete genome sequence of a Bangladesh-developed live-attenuated lumpy skin disease (LSD) vaccine strain.

Lumpy skin disease (LSD) in cattle is managed through live-attenuated vaccines. Bangladesh LSD vaccine was developed from LSD virus isolate Bangladesh LSD-29 by passaging 60 times in cell culture. Here, we report the complete genome sequence of Bangladesh LSD vaccine strain.

Climate-smart agriculture and food security in climate-vulnerable coastal areas of Bangladesh.

The issue of global climate change is increasingly worrisome, particularly for countries heavily reliant on agriculture. To reduce the negative impact of climate change on agriculture, farmers of Bangladesh started adopting different climate smart agriculture (CSA) practices. The CSA sustainably increases productivity, resilience, and food security, which can contribute to the achievement of a number of sustainable development goals (SDGs).

International Staging System Status and Trend of Relapse in Multiple Myeloma Cases in a Tertiary Level Health Care.

Multiple myeloma (MM) is a haematological neoplasm of mature B-cell lineage origin. It is characterized by abnormal clonal proliferation of plasma cells and presence of monoclonal protein in serum and / or urine. This study was conducted to observe the International Staging System (ISS) status and trends of relapse.

Nonequilibrium Self-Assembly of Microtubules Through Stepwise Sequential Interactions of DNA.

The assembly of biological systems forms nonequilibrium patterns with different functionalities through molecular-level communication via stepwise sequential interaction and activation. The mimicking of this molecular signaling offers extensive opportunities to design self-assemblies of bioinspired synthetic nonequilibrium systems to develop molecular robots with active, adaptive, and autonomous behavior. Herein, the design and construction of biomolecular motor system, microtubule (MT)-kinesin based molecular swarm system, are reported through stepwise sequential interactions of DNA.

Distinct amino acid substitutions in the EEV glycoprotein and DNA-dependent RNA polymerase of lumpy skin disease virus identified in wetland areas of Bangladesh.

The recent outbreak of lumpy skin disease virus (LSDV) in the wetland areas of Bangladesh presents a significant concern for both animal health and regional biosecurity. Epidemiological investigations into nine major outbreaks in the wetland areas revealed distinctive clinical symptoms in affected cattle, including elevated body temperature, excessive salivation, and the presence of skin nodules. Histopathological examination unveiled larger nodules compared to previous outbreaks, along with signs of secondary infection.

Food Consumption Patterns and Sedentary Behaviors Among the University Students: A Cross-Sectional Study.

Background: University is a critical period regarding unhealthy changes in eating behaviors in students. University students often face significant changes in their eating habits and physical activity levels, which can impact their overall health.

Aims: To investigate the eating habits and sedentary behavior of university students in Dhaka.

Impact of the COVID-19 outbreak on the field of hematopoietic cell transplantation in the Asia-Pacific region: APBMT Activity Survey 2020/2021.

COVID-19 became a global pandemic in 2020 and significantly affected the activity of hematopoietic cell transplants (HCT) worldwide. Despite these challenges, a total of 28,793 transplants, including 18,518 allogeneic and 10,275 autologous transplants, were performed in 719 facilities in 2020 in the Asia-Pacific (AP) region. This represented a 5.

RF-induced heating reduction by minimizing the external portion of the partially in and partially out medical devices under MRI at 1.5 T.

Purpose: To address the issue of RF-induced heating for partially in and partially out (PIPO) medical devices during 1.5 T MRI scans by proposing a method of minimizing the external portion.

Methods: A method of tightly winding the external segment of the PIPO device is proposed to minimize the overall device effective reception length during MRI scans to mitigate the RF-induced heating.

Fear of COVID-19 and mental health status among the medical students of a selected medical college in Bangladesh.

Background: COVID-19 pandemic and mental health of people are related to each other.

Aims: To assess the relationship between fear of COVID-19 (FCOV) and the psychological status of medical students of Bangladesh.

Methods: A total of 967 medical students and intern doctors of Sher-E-Bangla Medical College participated in this cross-sectional study.