Does exercise-induced severe ischaemia result in elevation of plasma troponin-T level in patients with chronic coronary artery disease?

Objective: It has been reported that the loss of cell membrane integrity during severe reversible ischaemia results in elevation of plasma troponin T (TnT) in unstable angina. We investigated whether TnT is released into circulation during severe ischaemia (e.g.

Glucocorticoid effects on the beta-adrenergic receptor-adenylyl cyclase system of human airway epithelium.

Background: Activation of the beta(2)-adrenergic receptor (beta(2)AR) system expressed by human airway epithelial cells elicits a variety of cyclic adenosine monophosphate (cAMP)-dependent processes that help determine airway caliber and the intensity of airway inflammation in asthma. Glucocorticoids, mainstays in the treatment of asthma, profoundly affect the expression and function of the beta(2)-adrenergic receptor-adenylyl cyclase (beta(2)AR-AC) system in a variety of cell types. However, the effects of glucocorticoids on the beta(2)AR-AC system expressed by human airway epithelial cells are unstudied.

Nuclear factor-kappa B augments beta(2)-adrenergic receptor expression in human airway epithelial cells.

Interleukin (IL)-1 beta increases beta(2)-adrenergic receptor (beta(2)-AR) mRNA and density by protein kinase C (PKC)-dependent mechanisms in human airway epithelial cells. The present study examined the role of several nuclear transcription factors in the PKC-activated upregulation of beta(2)-AR expression. BEAS-2B cells were exposed to the PKC activator phorbol 12-myristate 13-acetate (PMA; 0.

Fibrocartilaginous mesenchymoma of the distal femur: case report and literature review.

A case of a 9-year-old boy with fibrocartilaginous mesenchymoma located in the distal femur is presented. Fibrocartilaginous mesenchymoma is a rare tumor. There have been 17 cases reported since 1984.

Effect of melatonin implantation to sperm donor rams on post-thaw viability and acrosomal integrity of sperm cells in the breeding and non-breeding season.

The influence of melatonin administration to sperm donors on the freezability of ram semen and enzyme leakage through sperm cells during different steps of the cryopreservation process were evaluated in the breeding and non-breeding season. Melatonin implantation to rams in the breeding season improved post-thaw sperm viability and intact acrosome rates without influencing the motility rate (p < 0.05).

Erythropoietin for autologous blood donation in total hip arthroplasty patients.

Forty patients who were scheduled for a total hip arthroplasty were enrolled in a prospective study and were randomly divided into two groups. Group 1 received recombinant human erythropoietin (300 U/kg twice a week), and group 2 received placebo. The medication was started 2 weeks before the operation, and only one dose of medication was given after the operation.

IL-1beta enhances beta2-adrenergic receptor expression in human airway epithelial cells by activating PKC.

Protein kinase C (PKC)-activated signal transduction pathways regulate cell growth and differentiation in many cell types. We have observed that interleukin (IL)-1beta upregulates beta2-adrenergic receptor (beta2-AR) density and beta2-AR mRNA in human airway epithelial cells (e.g.

Influence of sugar supplementation of the extender on motility, viability and acrosomal integrity of dog spermatozoa during freezing.

Influence of different sugars supplemented to the extender on the motility, viability and intact acrosome rates of dog spermatozoa during dilution, equilibration and freezing was studied. The ejaculate was divided into 10 aliquots, which were diluted 1:3 with TRIS-citric acid extender containing 240 mMTRIS, 63 mM citric acid, 8% (v/v) glycerol, 20% (v/v) egg yolk and 70 mM sugar, which was either fructose, galactose, glucose, xylose (monosaccharide), lactose, trehalose, maltose, sucrose (disaccharide) or raffinose (trisaccharide). No sugar was added to the extender in the control group.

The attitudes of medical students to autopsy.

To assess the attitudes of medical students to autopsy, 6th year students in the Medical Schools located in Istanbul, Edirne and Bursa in Turkey were asked to participate in a questionnaire. In the questionnaire, the main questions were on the number of autopsies they had attended, the number of autopsies they had participated in, their reaction to the first autopsy, whether they felt the conditions were adequate or not and what would their objectives be upon deciding to perform an autopsy. In the evaluation, it was detected that most of the participants had attended an autopsy, only a minority had participated in autopsy and most of them felt uncomfortable and inadequate on performing autopsy.

Angiographic and scintigraphic (perfusion and electrocardiogram-gated SPECT) correlates of clinical presentation in unstable angina.

Background: Braunwald classification can be used as a measure of the acuteness or severity of clinical presentation of unstable angina. Gating perfusion images might provide additional information to that obtained from angiography, allowing correlations between the coronary anatomy and extent of myocardium at risk via simultaneous perfusion/function assessment.

Hypothesis: The aim of this study was to determine the relation between the highest levels of the Braunwald classification (class III = rest angina within 48 h of presentation; class C = postinfarction angina; class c = refractory angina) and the angiographic findings, and the extent ofperfusion and segmental wall motion abnormalities using technetium-99m ((99m)Tc) sestamibi-gated single-photon emission computed tomography (SPECT) imaging.

Chronic effects of inhaled albuterol on beta-adrenoceptor system function in human respiratory cells.

The in vivo effects of beta-adrenergic receptor (betaAR) agonists given chronically by metered-dose inhaler (MDI) on the molecular components of the beta-adrenoceptor system expressed by human respiratory cells are poorly understood. This study examined the effects of inhaled albuterol (180 microg four times daily for 7 days) on betaAR function of airway epithelial cells (AECs) and alveolar macrophages (AMs) freshly isolated from 10 normal subjects. Responses were related to beta2AR genotype in codons 16 and 27, regions which affect chronic responses to beta2-agonists.

Subtrochanteric valgus-extension osteotomy for neglected congenital dislocation of the hip in young adults.

Thirty-five patients with unilateral or bilateral neglected congenital dislocation of the hip (CDH) were treated with subtrochanteric valgus-extension osteotomy between 1975 and 1992. There were 29 females and 6 males in the group. A total of 50 osteotomies was performed.

Myocardial perfusion and angiographic findings in patients with paradoxical sinus deceleration during dobutamine technetium-99m sestamibi-gated SPECT imaging.

Aims: Dobutamine-gated SPECT imaging allows simultaneous perfusion and function assessment and is an alternative stress method for evaluating coronary artery disease in patients unable to perform treadmill exercise. In some patients, a paradoxical decrease in heart rate has been observed during high dose dobutamine infusion. The purpose of this study was to describe the paradoxical decrease in heart rate observed during dobutamine perfusion scintigraphy and determine its relation to inducible ischemia and angiographic coronary artery disease.

Relation of plasma lipoprotein(a) with myocardial viability and left ventricular performance in survivors of myocardial infarction.

Previous studies have reported that high serum lipoprotein(a) levels may be responsible for total occlusion of the infarct-related artery via inhibition of intrinsic fibrinolysis during acute myocardial infarction. We evaluated whether this would result in a greater extent of myocardial necrosis and impaired left ventricular function in patients with high lipoprotein(a) levels. Sixty-eight patients with prior myocardial infarction, who were not receiving thrombolytic therapy underwent coronary angiography and stress-redistribution-reinjection Tl-201 scintigraphy.

Influences of retrieval stages and glutathione addition on post-thaw viability of quick frozen mouse morula during in vitro culture.

Effects of the embryo retrieval stages and addition of glutathione (GSH) on post-thaw development of mouse morula were evaluated in 2 consecutive experiments. In the first experiment, 1-, 2-, 3- to 4- and 5- to 8-cell stage embryos were collected and cultured to the morula stage in Whitten's medium containing 0.1 mM ethylenediaminetetraacetic acid (EDTA).

Spermatic granuloma in the ram: diagnosis by ultrasonography and semen characteristics.

Ultrasonographic appearance of the testis and epididymis, and seminal characteristics, with regard to localization of spermatic granuloma were studied. In rams with spermatic granuloma (n = 9), diagnosed by clinical or ultrasonographic examinations before histopathological confirmation, localization of each lesion was recorded. Epididymal granulomas, caput and cauda, were seen as anechoic or hyperechoic areas with a distinct margin with or without a hyperechoic capsule.

Traumatic L1-L2 dislocation without fracture in a 6-year-old girl. Incomplete neurologic deficit and total recovery.

Study Design: A report of a rare complete dislocation of the first lumbar vertebra without fracture in a 6-year-old girl.

Objectives: To describe a rare traumatic lesion in children.

Summary Of Background Data: Although there has been a report of posterior dislocations of vertebra without fracture accompanied by anterior apophyseal splitting in young cadavers, all in the cervical region, to date, there has not been a reported clinical case of vertebral dislocation in the thoracolumbar region in a child.

Effects of topical corticosteroids on inflammatory mediator-induced eicosanoid release by human airway epithelial cells.

Background: Airway epithelial cells are among the first cells to come in contact with aerosolized corticosteroids. However, the relative potencies and time course of action of the several commonly used aerosolized corticosteroids on eicosanoid production by airway epithelial cells are unknown.

Objectives: This study compared the effects of fluticasone, budesonide, and triamcinolone on eicosanoid output by human airway epithelial cells in vitro.

Fracture of the ossified Achilles tendon.

The authors report a fracture of an ossified Achilles tendon in a 44-year-old male patient who was admitted to the hospital after a minor injury with pain on the posterior aspect of his left calf. Examination disclosed a fracture of the ossified Achilles tendon. Plain roentgenogram and MRI confirmed Achilles tendon ossification and fracture at the distal one-third of the tendon.

Assessment of Graft Patency Rate After Coronary Artery Bypass Surgery by Exercise TL-201 Single Photon Emission Computed Tomography.

Noninvasive assessment of graft function requires detection of myocardial ischemia. Although T1-201 scintigraphy was primarily used to demonstrate improved perfusion soon after bypass surgery, it may be important in detecting graft stenosis late after surgery, identifying patients with symptoms due to graft occlusion. To investigate this, 38 symptomatic patients aged 58 +/- 10 years who had undergone bypass surgery 3-7 years previously (mean 4.

Aggressive bowel preparation does not enhance bacterial translocation, provided the mucosal barrier is not disrupted: a prospective, randomized study.

Purpose: Prospective, randomized studies have shown that bowel preparation may adversely affect infectious complications following colonic resections. However, very little is known about the effects of bacterial translocation on these infectious complications. The aim of this prospective, randomized study was to assess the effects of bowel preparation on bacterial translocation.

Arthroscopic partial resection of the discoid meniscus in children.

Thirteen children with 14 lateral discoid menisci were reviewed at an average follow-up of 2.7 years. Their average age at the time of the operation was 12.

Treatment of congenital dislocation of the hip. Results of closed reduction and immobilization in the hip spica cast.

Treatment of congenital dislocation of the hip (CDH) by closed reduction and immobilization in the hip spica cast is one of the accepted methods for use in patients under one year of age. We report 74 congenitally dislocated hips treated with premanipulation skin traction, closed reduction under anesthesia, adductor tenotomy and immobilization in the hip spica cast. Satisfactory results were obtained in 60 hips.

IL-1 beta alters beta-adrenergic receptor adenylyl cyclase system function in human airway epithelial cells.

Inflammatory cells release a variety of cytokines, including interleukin (IL)-1 beta, into the airway in asthma. This study examined the effects of human IL-1 beta on the function of the beta-adrenergic receptor (beta AR)-adenylyl cyclase (AC) system in BEAS-2B cells, a human airway epithelial cell line. IL-1 beta markedly increased beta AR density (Bmax; P < 0.