Publications by authors named "Akshitha Maddula"
Anesthesiology
November 2024
Article Synopsis
- Neuropeptide Y Y2 receptor antagonist BIIE0246 has a complex role in nociception, acting as both an inhibitor and facilitator depending on the presence of inflammation or nerve injury.
- In experiments with mice, BIIE0246 induced hypersensitivity and nociceptive behaviors in healthy mice while blocking Y2 receptors significantly curtailed these responses after surgery or nerve injury.
- The research suggests that Y2 receptors in sensory neurons initially provide inhibition of pain but may switch to promote heightened pain sensitivity (hyperalgesia) in certain pain models.
