Publications by authors named "Akshita Kalyan"
Article Synopsis
- New technologies are being developed that can detect tiny pieces of tumor DNA in blood, which could help doctors make better treatment decisions for cancer patients.
- A new test called FoundationOne®Tracker can track changes in this tumor DNA without needing extra samples from patients, which makes it easier and faster to get results.
- The test is really accurate, with 99.6% specificity and over 97% sensitivity, meaning it works well to find the tumor DNA in blood samples.
We analyzed maternal plasma cell-free DNA samples from twin pregnancies in a prospective blinded study to validate a single-nucleotide polymorphism (SNP)-based non-invasive prenatal test (NIPT) for zygosity, fetal sex, and aneuploidy. Zygosity was evaluated by looking for either one or two fetal genome complements, fetal sex was evaluated by evaluating Y-chromosome loci, and aneuploidy was assessed through SNP ratios. Zygosity was correctly predicted in 100% of cases (93/93; 95% confidence interval (CI) 96.
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