Basal Linear Deposit: Normal Physiological Ageing or a Defining Lesion of Age-Related Macular Degeneration?

To determine if basal linear deposit (BLinD) is a specific lesion of age-related macular degeneration (AMD). The cohort was selected from a clinically and histopathologically validated archive (Sarks Archive) and consisted of 10 eyes (age 55-80 years) without any macular basal laminar deposit (BLamD) (Sarks Group I) and 16 eyes (age 57-88 years) with patchy BLamD (Sarks Group II). Only eyes with in vivo fundus assessment and corresponding high-resolution transmission electron microscopy (TEM) micrographs of the macula were included.

The effects of a highly bioavailable curcumin Phytosome preparation on the retinal architecture and glial reactivity in the GFAP-IL6 mice.

Uncontrolled, chronic inflammation in the retina can disturb retinal structure and function leading to impaired visual function. For the first time, in a mouse model of chronic neuroinflammation (GFAP-IL6), we investigated the impact of chronic glial activation on the retinal microglia population and structure. In addition, we tested a curcumin Phytosome preparation with enhanced bioavailability to investigate the effects of a cytokine-suppressing anti-inflammatory drug on retinal architecture.

Extended Depth-of-Focus Intraocular Lens Implantation in Patients with Age-Related Macular Degeneration: A Pilot Study.

Purpose: To assess visual outcomes of the implantation of a non-diffractive extended depth of focus (EDOF) intraocular lens (IOL) in patients with age-related macular degeneration (AMD).

Setting: Ophthalmology practice, Sydney, Australia.

Design: Retrospective chart review.