Publications by authors named "Akshay Rahul Nandi"
Advances in the field of oncology have led to the advent of doxorubicin (DOX), an anthracycline chemotherapeutic agent, through which cancer survival rates have remarkably improved. There has, however, been a rise in adverse effects from the use of DOX, most notably cardiotoxicity. DOX-induced cardiotoxicity is thought to arise through the generation of reactive oxygen species (ROS), causing mitochondrial dysfunction in the cardiomyocytes.
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- Castleman disease (CD) is a rare group of disorders involving lymphoid tissue proliferation, which can be categorized into unicentric and multicentric forms, with idiopathic multicentric Castleman disease (iMCD) being particularly difficult to diagnose and treat.
- A case study describes a 23-year-old woman with a history of iron deficiency anemia who presented with antiphospholipid syndrome and tested positive for human herpesvirus-6, ultimately leading to the diagnosis of the plasma cell variant of CD after finding a gastric mass.
- The effective treatment with siltuximab and tocilizumab underscores the importance of interleukin-6 in CD's complex etiology and highlights the need for early diagnosis of APS in
Article Synopsis
- Evans syndrome (ES) involves autoimmune hemolytic anemia and immune thrombocytopenia due to immune dysregulation that leads to antibodies against blood cells.
- A case study of a 38-year-old male showed symptoms like shortness of breath and weakness, with findings indicating ES, including hemolysis and thrombocytopenia.
- Treatment typically starts with corticosteroids and may include additional therapies for resistant cases, emphasizing the need for tailored monitoring and management to achieve remission and reduce relapses.