Publications by authors named "Akshay Govindan"
Article Synopsis
- DNA methylation is crucial for maintaining cellular identity, but it's often disrupted in tumors and linked with other genetic changes.
- Researchers analyzed 687 tumors and adjacent normal tissues across various organs to create a Pan-Cancer catalog, highlighting specific methylation patterns.
- They discovered that certain methylation changes are associated with cancer characteristics, such as hypomethylated FGFR2 in endometrial cancer and hypermethylated STAT5A leading to immune suppression in squamous tumors, revealing the importance of methylation in tumor behavior.
Article Synopsis
- Post-translational modifications (PTMs) significantly influence cell signaling and physiology in both healthy and cancerous cells, with recent advancements in mass spectrometry allowing for precise analysis of these modifications.* -
- This study utilizes the largest dataset of proteogenomics from 1,110 cancer patients to uncover widespread patterns of protein changes, particularly focusing on acetylation and phosphorylation across 11 cancer types.* -
- Findings show that specific cancer types exhibit unique PTM-related alterations linked to processes like DNA repair, immune response, kinase activity, and histone regulation, suggesting new potential therapeutic targets.*
Background: Differentiating true glioblastoma multiforme (GBM) from pseudoprogression (PsP) remains a challenge with current standard magnetic resonance imaging (MRI). The objective of this study was to explore whether patients' absolute lymphocyte count (ALC) levels can be utilized to predict true tumor progression and PsP.
Methods: Patients were considered eligible for the study if they had 1) GBM diagnosis, 2) a series of blood cell counts and clinical follow-ups, and 3) tumor progression documented by both MRI and pathology.