Publications by authors named "Akshatha H S"
Article Synopsis
- - The study focuses on inhibiting DprE1, a crucial enzyme in the synthesis of cell wall components in mycobacteria, which include the bacteria causing tuberculosis.
- - Researchers synthesized and tested 15 new compounds targeting DprE1, with two compounds (BOK-2 and BOK-3) showing promising inhibition at low concentrations (IC values of 2.2 and 3.0 μM, respectively).
- - The research utilized molecular modeling to understand how these compounds interact with DprE1, paving the way for potential new treatments for tuberculosis through targeted drug design.
Mycobacterium tuberculosis (Mtb) has numerous cell wall and non-cell wall mediated receptors for drug action, of which cell wall mediated targets were found to be more promising because of their pivotal role in bacterial protection and survival. Herein, we reported the design and synthesis of a series of pyrazole-linked triazoles based on the reported structural features of promising drug candidates that target DprE1 receptors through a Structure-based drug design (SBDD) approach (6a-6j and 7a-7j). The synthesized compounds were evaluated for their in-vitro antitubercular activity against virulent strains of Mtb H37Rv.
View Article and Find Full Text PDFLysophosphatidic acid (LPA) activates six LPA receptors (LPAR) and regulates various cellular activities such as cell proliferation, cytoprotection, and wound healing. Many studies elucidated the pathological outcomes of LPA are due to the alteration in signaling pathways, which include migration and invasion of cancer cells, fibrosis, atherosclerosis, and inflammation. Current pathophysiological research on LPA and its receptors provides a means that LPA receptors are new therapeutic targets for disorders associated with LPA.
View Article and Find Full Text PDFDengue virus belongs to the class of RNA viruses and subclass of enveloped single-stranded positive-sense RNA virus. It causes dengue fever (DF), dengue hemorrhagic fever (DHF), or dengue shock syndrome (DSS), where DHF and DSS are life-threatening. Even though dengue is an age-old disease, it is still a mystery and continues to be a global threat.
View Article and Find Full Text PDFBackground: Pheniramine abuse is reported not only in patients with psychiatric disorders but also in the general population.
Case Report: We report a case of pheniramine dependence in a patient with obsessive-compulsive disorder. The patient took about 250 mg orally daily and injected about 90 mg every week from the last six months.