Conceptualizing multi-level determinants of infant and young child nutrition in the Republic of Marshall Islands-a socio-ecological perspective.

The East and Pacific region includes 14 Pacific Island Countries where, between 2000 and 2016, indicators of stunting, wasting, and micronutrient deficiencies have plateaued or worsened, while rates of overweight, obesity, and associated disease have risen. The Republic of Marshall Islands (RMI) is no exception: maternal and child nutrition indicators have not improved in decades. A study of the contemporary factors shaping the RMI nutrition situation was needed for informing policy and tailoring interventions.

Derivation of a System-Independent for P-glycoprotein Mediated Digoxin Transport from System-Dependent IC Data.

It has been previously demonstrated that IC values for inhibition of digoxin transport across confluent polarized cell monolayers are system-dependent. Digoxin IC data from five laboratories participating in the P-glycoprotein (P-gp) IC Initiative, using Caco-2, MDCKII-hMDR1 or LLC-PK1-hMDR1 cells, were fitted by the structural mass action kinetic model for P-gp-mediated transport across confluent cell monolayers. We determined their efflux-active P-gp concentration [T(0)], inhibitor elementary dissociation rate constant from P-gp (), digoxin basolateral uptake clearance (), and inhibitor binding affinity to the digoxin basolateral uptake transporter ().