Publications by authors named "Akshat Sinha"
Background: Alström syndrome (AS) is a recessively inherited genetic condition which is ultra-rare and extremely complex. Symptoms include retinal dystrophy, nystagmus, photophobia, hearing loss, obesity, insulin resistance, diabetes and cardiomyopathy. The condition is progressive, but it is important to note that not all the complications associated with AS occur in everyone affected.
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- - Colorectal cancer (CRC) is common with poor prognosis in advanced stages, and current screening methods have limitations in differentiating between benign and malignant growths, leading to unnecessary procedures.
- - A systematic review of 10 studies (1714 samples) revealed that taurine levels were significantly higher in CRC patients, making it a potential diagnostic metabolite for the disease across various stages.
- - The findings suggest that increased taurine concentration is associated with a higher likelihood of CRC and emphasize the need to explore taurine and other bile acid metabolites for diagnostic purposes, including their relationship with the microbiome.