Background: Many women with migraine experience a change in migraine frequency associated with the menstrual cycle. This study was undertaken to study the effect of vitamin E as a prophylactic agent on women with menstrual migraine.
Material/method: During a placebo-controlled double-blinded trial, 72 women with menstrual migraine received placebo (identical in appearance to vitamin E) daily for five days, two days before to three days after menstruation for two cycles followed by a one-month wash-out and one vitamin E softgel (400 IU) daily for five days in the next two cycles.