Inflammatory and Non-inflammatory Breast Cancer: A Potential Role for Detection of Multiple Viral DNAs in Disease Progression.

Background: Inflammatory breast cancer (IBC) is the most lethal form of breast cancer. Multiple viral infections in IBC tissues were found to be associated with disease pathogenesis.

Objective: The aim of the present study was to correlate the incidence of viral DNA with breast cancer progression.

Inflammatory breast cancer: high incidence of detection of mixed human cytomegalovirus genotypes associated with disease pathogenesis.

Inflammatory breast cancer (IBC) is a highly metastatic, aggressive, and fatal form of breast cancer. Patients presenting with IBC are characterized by a high number of axillary lymph node metastases. Recently, we found that IBC carcinoma tissues contain significantly higher levels of human cytomegalovirus (HCMV) DNA compared to other breast cancer tissues that may regulate cell signaling pathways.

Promoter hypermethylation and suppression of glutathione peroxidase 3 are associated with inflammatory breast carcinogenesis.

Reactive oxygen species (ROS) play a crucial role in breast cancer initiation, promotion, and progression. Inhibition of antioxidant enzymes that remove ROS was found to accelerate cancer growth. Studies showed that inhibition of glutathione peroxidase-3 (GPX3) was associated with cancer progression.

Prevalence and pattern of lymph node metastasis in malignant pleural mesothelioma.

Background: The incidence and pattern of nodal metastases in mesothelioma are not well understood. This study was conducted to evaluate the prevalence and pattern of nodal metastasis in mesothelioma patients.

Methods: The study included 53 patients with mesothelioma.

Time-trend in epidemiological and pathological features of schistosoma-associated bladder cancer.

Objective: To investigate the different emerging trends in the features of bladder cancer along 17 years.

Patients And Methods: During a 17-year period (1988- 2004), 5071 epithelial bladder cancer patients underwent radical cystectomy at the National Cancer Institute (NCI), Cairo University, Egypt. The time was divided into 3 time periods to detect changes of the clinicopathologic features of patients in these periods.

A comparative study of rectal and colonic carcinoma: demographic, pathologic and TNM staging analysis.

Objective: The aim is to determine the relative frequency of rectal carcinoma in a large recent surgical series. In addition, rectal carcinoma is compared with colonic carcinoma with regard to demographic data, histological types and TNM stages.

Patients And Methods: A retrospective pathologic study was conducted on 215 patients with colorectal carcinomas, all treated by radical surgery during the years 2003-2005.

Hepatitis C virus and its genotypes and Helicobacter pylori in pediatric non-Hodgkin's lymphoma: could there be a possible etiologic role?

Background: It has been recently hypothe-sized that Helicobacter pylori (H. pylori) and Hepatitis C virus (HCV) might be involved in the pathogenesis of malignant non-Hodgkin's lymphoma (NHL). However, most of the studies were carried out on adult patients.

Multidisciplinary treatment in children with non-metastatic hepatoblastoma: treatment results at the National Cancer Institute, Cairo University.

Purpose: The aim of this study is to evaluate our experience at the NCI, Cairo University in the management of non- metastetic hepatoblastoma (HB). Also to improve survival of children with HB and reduce the operative morbidity and mortality by using preoperative chemotherapy.

Patients And Methods: After biopsy and assessment of the extent of disease, all patients were treated with a 6-hour continuous intravenous infusion of cisplatin (PLA) 90mg/m2 on day one followed by doxorubicin (DO) 20mg/m2 per day administered as 1- hour infusion on days 2,3 and 4.

Midfacial degloving approach for malignant maxillary tumors.

Purpose: The aim of this work is to study the use of this technique in extirpation of malignant tumors of the maxillary sinus. This includes the exposure for adequate tumor resection and the preservation of as much as possible functional tissue integrity. This approach will be evaluated including the advantages and disadvantages as regards the physiological function, aesthetic outcome and the complications related to the procedure.