Large language models vs human for classifying clinical documents.

Background: Accurate classification of medical records is crucial for clinical documentation, particularly when using the 10th revision of the International Classification of Diseases (ICD-10) coding system. The use of machine learning algorithms and Systematized Nomenclature of Medicine (SNOMED) mapping has shown promise in performing these classifications. However, challenges remain, particularly in reducing false negatives, where certain diagnoses are not correctly identified by either approach.

Deep learning-based skin lesion analysis using hybrid ResUNet++ and modified AlexNet-Random Forest for enhanced segmentation and classification.

Skin cancer is considered globally as the most fatal disease. Most likely all the patients who received wrong diagnosis and low-quality treatment die early. Though if it is detected in the early stages the patient has fairly good chance and the aforementioned diseases can be cured.

Therapeutic drug monitoring of vancomycin in surgical patients using a validated HPLC method.

Background: Vancomycin is being used for the treatment of a variety of infections caused by methicillin resistant and methicillin susceptible . Therapeutic drug monitoring (TDM) is highly recommended for ensuring the safe and effective therapy with vancomycin. A reliable and cost-effective bioanalytical method is required for TDM as well as pharmacokinetic studies of vancomycin.

Genome-wide identification of CCO gene family in cucumber (Cucumis sativus) and its comparative analysis with A. thaliana.

Carotenoid cleavage oxygenase (CCO) is an enzyme capable of converting carotenoids into volatile, aromatic compounds and it plays an important role in the production of two significant plant hormones, i.e., abscisic acid (ABA) and strigolactone (SL).

Morphoanatomical and Physiological Adaptations of L. against Allelopathic Extract of L. (Horse purslane).

Weed infestation can be harmful to crop growth and cause severe losses in yield by absorbing nutrients and releasing inhibitory secondary metabolites and thus needs to be controlled for food security. The use of synthetic herbicides is one of the most widely applied methods, but its frequent usage is a serious threat to health and the environment and develops resistance in weeds. Allelopathy is an eco-friendly bio-control method, and extracts are known to be effective against various weeds in the crop of (wheat), but their effect on the main crop (wheat) is still unknown.

The pathological role of C-X-C chemokine receptor type 4 (CXCR4) in colorectal cancer (CRC) progression; special focus on molecular mechanisms and possible therapeutics.

Colorectal cancer (CRC) is comprised of transformed cells and non-malignant cells including cancer-associated fibroblasts (CAF), endothelial vasculature cells, and tumor-infiltrating cells. These nonmalignant cells, as well as soluble factors (e.g.

Antifungal activity of green synthesized selenium nanoparticles and their effect on physiological, biochemical, and antioxidant defense system of mango under mango malformation disease.

Plant extract-based green synthesis of nanoparticles is an emerging class of nanotechnology that has revolutionized the entire field of biological sciences. Green synthesized nanoparticles are used as super-growth promoters and antifungal agents. In this study, selenium nanoparticles (SeNPs) were synthesized using Melia azedarach leaves extract as the main reducing and stabilizing agent and characterized by UV-visible spectroscopy, scanning electron microscopy (SEM), X-ray diffraction (XRD), energy-dispersive X-ray (EDX), and fourier transform infrared spectrometer (FTIR).

The value of prognostic and predictive parameters in early-stage lung adenocarcinomas: A comparison between biopsies and resections.

Introduction: Since lung adenocarcinoma (LUAD) biopsies are usually small, it is questionable if their prognostic and predictive information is comparable to what is offered by large resection specimens. This study compares LUAD biopsies and resection specimens for their ability to provide prognostic and predictive parameters.

Methods: We selected 187 biopsy specimens with stage I and II LUAD.

comparative evaluation of extracts for antioxidant and antidiabetic activity.

known as Jhau is traditionally used as expectorant, liver tonic, laxative, astringent, and antidiarrheal. The current study was proposed to determine the antioxidant, antidiabetic properties of the methanolic, ethanolic, and aqueous extracts of arial part, subsequently the phytochemical evaluation. Hence, arial part extracts were extracted with methanol (MthTg), ethanol (EthTg), and distilled water (AqTg).

Supplementation of banana peel powder for the development of functional broiler nuggets.

Banana peel powder is considered one of the most nutritive and effective waste product to be utilized as a functional additive in the food industry. This study aimed to determine the impact of banana peel powder at concentrations of 2%, 4%, and 6% on the nutritional composition, physicochemical parameters, antioxidant potential, cooking properties, microbial count, and organoleptic properties of functional nuggets during storage at refrigeration temperature for 21 days. Results showed a significant increase in nutritional content including ash and crude fiber ranging from 2.

The Hepatoprotective and Anti-Nephrotoxic Potential of Methanolic Extract of a Polyherbal Preparation in CCl-Induced Liver Injury Model of Wistar Rats.

The liver and kidneys are the vital organs of the body and perform important life-sustaining functions in the body. Synthetic drugs used in the treatment of liver and kidney diseases are sometimes inadequate and can lead to serious side effects. Medicinal herbs and plants were used to combat diseases for a long time and combination therapy is preferred over single plant therapy.

Preparation of Polyvinylidene Fluoride Nano-Filtration Membranes Modified with Functionalized Graphene Oxide for Textile Dye Removal.

Water scarcity has become one of the most significant problems globally. Membrane technology has gained considerable attention in water treatment technologies. Polymeric nanocomposite membranes are based on several properties, with enhanced water flux, high hydrophilicity and anti-biofouling behavior, improving the membrane performance, flexibility, cost-effectiveness and excellent separation properties.

Fabrication and Characterization of Sulfonated Graphene Oxide (SGO) Doped PVDF Nanocomposite Membranes with Improved Anti-Biofouling Performance.

Emergence of membrane technology for effective performance is qualified due to its low energy consumption, no use of chemicals, high removal capacity and easy accessibility of membrane material. The hydrophobic nature of polymeric membranes limits their applications due to biofouling (assemblage of microorganisms on surface of membrane). Polymeric nanocomposite membranes emerge to alleviate this issue.

Functional positional eye and eyelid movements.

Background: Positional manoeuvres are an important part of the neurological examination, particularly in patients with vertigo where the presence and characteristics of provoked nystagmus can help differentiate central from peripheral neurological disorders.

Methods: Case series of functional positional eye and eyelid movements.

Results: We report four patients with functional eye and eyelid movements provoked during positional manoeuvres.

Genetic transformation of gene in a high yielding susceptible cultivar of commercial wheat ( L.).

In this study, the gene was isolated and prepared for transformation in disease-susceptible commercial high-yielding wheat ( L.) cultivar Lasani-2008. The fragment was initially inserted in plasmid pUC57 for sequence confirmation before performing further experiments.

and polymorphisms and clopidogrel resistance in ischemic heart disease patients.

Polymorphisms in and genes are thought to be involved in clopidogrel high on treatment reactivity in ischemic heart disease (IHD) patients. A total of 240 patients with IHD were screened for loss-of-function alleles (LOF; *2, *3) and Q192R. Patients were classified as responders and nonresponders to clopidogrel based upon platelet aggregation studies.

Antihyperglycemic Activity of Hydroalcoholic Extracts of Selective Medicinal Plants , , , and and Their Polyherbal Preparation in Alloxan-Induced Diabetic Mice.

Background: Diabetes mellitus is a metabolic disorder associated with relative or absolute insulin deficiency or resistance, characterized by hyperglycemia. Modern prescriptions such as pioglitazone have better therapeutic potential, but its side effects and financial burden for developing countries have motivated the researchers to find alternative natural drugs to compete hyperglycemia in patients with diabetes. The present study was conducted to explore the therapeutic potential of selected medicinal plants for the treatment of diabetes as an alternative to allopathic medicines.

Phytochemical analysis and hepatoprotective effect of polyherbal formulation on CCl4 induced hepatotoxicity in mice.

The potent phytotherapeutic modalities against the hepatotoxicity have motivated us to explore numerous plants and polyherbal preparations because conventional drug discovery is more expensive and tedious. So, this study was conducted to evaluate the hepatoprotective potential of a polyherbal formulation (PHF), comprising of Solanum nigrum, Silybum marianum, Atrmesia absinthium, Achillea millifolium and Cichorium intybus against carbon tetrachloride(CCl4) induced hepatotoxicity in experimental rats. CCl4intoxicationinduced vacuole formation and fastdegeneration so selective liver enzymes including alanine aminotransferase (ALT) and aspartate aminotransferase (AST), alkalinephosphatase (ALP) and total bilirubin in rat's plasma,as well as liver histological architecture, were used to evaluate the effect of herbal treatments with different doses (ranging 100-500 mg/kg) for two weeks.

Antipyretic potential of herbal coded formulation (Pyrexol).

The antipyretic effect of the aqueous extract of herbal coded formulation containing equal amount of Salix alba, Emblica officinalis, Glycyrrhiza glabra, Adhatoda vasica, Viola odorata, Thea sinensis, Veleriana officinalis, Foeniculum vulgare, Sisymbrium irrio and Achillea millefolium was investigated using the yeast induced pyrexia model in rabbits. Paracetamol was used as a control group. Rectal temperatures of all rabbits were recorded immediately before the administration of the extract or paracetamol and again at 1 hour, after this, temperature was noted at 1 hrs interval for 5 hrs using digital thermometer.

Review-Medicinal plants and management of Diabetes Mellitus: A review.

Diabetes is a metabolic disorder characterized by chronic hyperglycemia and associated with dysfunction and failure of various body organs. Alarming increase in prevalence rate has made this disorder a major health problem globally. The available treatment modalities are not sufficient to combat diabetes and associated complications.

Intralesional Versus Oral Chloroquine in Cutaneous Leishmaniasis: Comparison of Outcome, Duration of Treatment and Total Dose of Drug.

Objective: To compare intralesional versus oral chloroquine in cutaneous leishmaniasis and determine the cure rate, duration of treatment, and total dose of drug.

Study Design: Randomized controlled study.

Place And Duration Of Study: Department of Dermatology, Sheikh Zayed Medical College/Hospital, Rahim Yar Khan, from November 2013 to June 2014.