Experimental investigations on a sequential combination chemotherapy protocol.

This paper deals with experimental investigations concerning the composition of a cytostatic three-drug-protocol in diploid Ehrlich-Ascites-Tumor (EAT) cells in vivo at a far advanced stage of the disease. Hydroxyurea (HU) and vincristine (VCR) were used in very low doses to induce a modification of the growth pattern of tumor cells alike partial synchronization. Adriamycin (ADM) was selected as cytocidal drug during DNA synthesis of the partially synchronized cells.

The high prevalence of HLA-B5 in Behçet's disease.

Sixteen of the nineteen (84%) patients with Behçet's disease in Turkey had HLA-B5; the prevalence of HLA-B5 among 150 controls was 27%.