Transcriptome Profiling Reveals Interplay of Multifaceted Stress Response in on Exposure to Glutathione and Ciprofloxacin.

We have previously reported that supplementation of exogenous glutathione (GSH) promotes ciprofloxacin resistance in by neutralizing antibiotic-induced oxidative stress and by enhancing the efflux of antibiotic. In the present study, we used a whole-genome microarray as a tool to analyze the system-level transcriptomic changes of on exposure to GSH and/or ciprofloxacin. The microarray data revealed that GSH supplementation affects redox function, transport, acid shock, and virulence genes of .