Inhibition of 15-prostaglandin dehydrogenase attenuates acetaminophen-induced liver injury via suppression of apoptosis in liver endothelial cells.

Hepatic microvascular disruption caused by injury to liver sinusoidal endothelial cells (LSECs) is an aggravating factor for drug-induced liver injury (DILI). It is suggested that prostaglandin E (PGE) may be able to attenuate LSEC injury. However, it is also known that 15-keto PGE, a metabolite of PGE produced by 15-prostaglandin dehydrogenase (15-PGDH) that is not a ligand of PGE receptors, suppresses inflammatory acute liver injury as a ligand of peroxisome proliferator-activated receptor γ.