Publications by authors named "Akito Ichiki"
Background: The two-drug regimen of dolutegravir/lamivudine (DTG/3TC) is currently an optional antiretroviral therapy (ART). Despite its reported advantages on body weight and lipid profile, the same effects have not yet been reported for Asian population.
Methods: We conducted a single-center retrospective study involving Japanese people living with HIV (PLWH).
Article Synopsis
- A study was conducted on Japanese people living with HIV to compare body weight changes when switching from tenofovir disoproxil fumarate (TDF) to tenofovir alafenamide fumarate (TAF) while on antiretroviral therapy.
- The results showed no significant overall difference in weight gain between TDF and TAF; however, younger patients (<50 years) experienced greater weight gain on TAF compared to older patients.
- The study concludes that while switching to TAF does not generally lead to weight gain, using it alongside dolutegravir (DTG) may correlate with increased weight gain, especially in younger populations.
Article Synopsis
- A 51-year-old man admitted for visual field narrowing and papilledema was diagnosed with right transverse and sigmoid sinus thrombosis after undergoing brain MRI; he initially received intravenous heparin therapy.
- His condition worsened on day 9 with a seizure and decreased platelet count, leading to suspicion of heparin-induced thrombocytopenia (HIT), despite negative immunological antibody tests.
- Treatment switched from heparin to argatroban due to HIT diagnosis, followed by warfarin, and eventually to rivaroxaban to manage anticoagulation without complications.
Article Synopsis
- A Japanese patient with HIV-related Kaposi sarcoma presented with multiple skin lesions and significant swelling in both groin areas.
- The patient underwent extensive treatment with pegylated liposomal doxorubicin (PLD) over 10 years, exceeding the standard lifetime dosage without experiencing serious side effects.
- Ultimately, the patient passed away from pancreatic cancer rather than complications from the KS or the treatments received.
Protein S (PS) gene (PROS1) is found on chromosome 3 (3q11.1). To date, the reported detection rate of causative gene mutations in patients suspected of PS deficiency is only approximately 50%.
View Article and Find Full Text PDF[Syphilis Testing and High Rate of Infection Among HIV-infected Patients].
Kansenshogaku Zasshi
November 2016
Article Synopsis
- * A study at Tokyo Medical University Hospital analyzed data from 1,000 HIV-infected male patients, finding that 77.4% were tested for syphilis multiple times, with 61.3% reactive to syphilis tests.
- * Among those who tested reactive, 12.9% were either newly diagnosed with syphilis or had repeated infections, indicating the need for regular STD screening as recommended by guidelines.
Neisseria elongata, a normal resident in the human oral cavity, rarely causes invasive infections. We herein report a case of endocarditis caused by Neisseria elongata subsp. nitroreducens that occurred in a patient without any apparent cardiac complications.
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