Publications by authors named "Akito Hisanaga"

Article Synopsis
  • A randomized controlled trial tested the effects of Kampo medicine (kakkonto and shosaikotokakikyosekko) combined with standard treatment for COVID-19 symptom relief.
  • The post hoc analysis revealed that symptoms disappeared faster in the Kampo group compared to the control group, though these results weren't statistically significant overall.
  • Specific symptoms like fever and shortness of breath showed significantly faster disappearance with Kampo treatment, particularly in unvaccinated patients, highlighting its potential benefits for acute COVID-19.
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The traditional Japanese (Kampo) medicine, kakkonto with shosaikotokakikyosekko, has antiviral and anti-inflammatory effects. In this randomized trial, patients with mild and moderate coronavirus disease (COVID-19) were randomly allocated to the control group receiving conventional treatment for symptom relief such as antipyretics and antitussives or the Kampo group receiving mixed extract granules of kakkonto (2.5 g) and shosaikotokakikyosekko (2.

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Objective Patients in whom coronavirus disease 2019 (COVID-19) was suspected or confirmed between January 1, 2020, and October 31, 2021, were enrolled from Japanese hospitals in this multicenter, retrospective, observational study. Methods Data on the treatment administered (including conventional and Kampo medicine) and changes in common cold-like symptoms (such as fever, cough, sputum, dyspnea, fatigue, and diarrhea) were collected from their medical records. The primary outcome was the number of days without a fever (with a body temperature <37°C).

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Article Synopsis
  • COVID-19 hit Japan in 2020, resulting in over 250,000 infections and 3,500 deaths, prompting the implementation of infection control measures and the development of treatments and vaccines.
  • Kampo medicine, a traditional Japanese practice, is being explored for its antiviral and anti-inflammatory properties, with research focusing on its potential effectiveness in managing COVID-19.
  • Case reports reviewed showed that 22 patients received Kampo treatments in conjunction with Western medicine, and ongoing studies by the Japan Society for Oriental Medicine are investigating its use in various stages of COVID-19 treatment and recovery.
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Keishibukuryogan (KBG; Guizhi-Fuling-Wan in Chinese) is one of the Kampo (Japanese traditional) medicines used to treat patients with climacteric syndrome. KBG can be used by patients who cannot undergo hormone replacement therapy due to a history of breast cancer. We evaluated whether cytosine-adenine (CA) repeat polymorphism of the estrogen receptor β gene can be a predictor of the beneficial effect of KBG on climacteric syndrome.

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Community-based surveys were performed in seven rural areas in Japan to investigate the prevalence of dementia and illnesses causing dementia. A total of 5431 elderly subjects were selected based on census data from 1 October 2009. In total, 3394 participants were examined (participation rate: 62.

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Kampo medicines have been used to treat patients with psychogenic disorders from ancient times. In the present report the cases are described of four patients with panic disorder successfully treated with Kampo medicines. These four patients fulfilled the Diagnostic and Statistical Manual of Mental Disorders (DSM) criteria for panic disorder with agoraphobia.

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A case of sleep choking syndrome with typical symptoms is presented. A 44-year-old Japanese male suffered from multiple episodes of choking, which suddenly appeared with fear of impending death about 30 min after falling asleep almost every night. Overnight polysomnography showed an apnea index of 0.

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