Publications by authors named "Akito Asato"
Background/aim: Endoscopic submucosal dissection (ESD) followed by chemoradiotherapy (CRT) has become a promising treatment modality in the management of early-stage superficial esophageal squamous cell carcinoma (SESCC). However, radiotherapy often leads to significant adverse events (AEs), including cardiopulmonary toxicity, limiting the delivery of this treatment modality. This study aimed to evaluate the efficacy of reduced-volume radiotherapy and dose-dense chemotherapy in mitigating AEs for high-risk SESCC following ESD.
View Article and Find Full Text PDFArticle Synopsis
- Esophagectomy is typically the go-to treatment for superficial esophageal squamous cell carcinoma (SESCC) after noncurative endoscopic submucosal dissection (ESD), but recent studies suggest that chemoradiotherapy (CRT) may also be effective.
- This study compared the long-term outcomes of 60 SESCC patients who received either CRT or esophagectomy following noncurative ESD, finding that overall and disease-free survival rates were similar between the two treatment groups.
- Results indicated that CRT could be a promising non-surgical alternative for treating high-risk SESCC patients, suggesting the need for more research in this area.
Definitive Radiotherapy for Penoscrotal Extramammary Paget's Disease: A Case Report with Long-Term Follow-Up.
Clin Med Insights Case Rep
April 2021
Penoscrotal extramammary Paget's disease (EMPD) is a rare intraepithelial adenocarcinoma in older male patients, and no effective nonsurgical treatment strategies are currently available. The aim of this study was to report the usefulness of external radiotherapy (RT) for penoscrotal EMPD in an inoperable elderly patient. This report presents the treatment of an 89-year-old man with widespread penoscrotal EMPD.
View Article and Find Full Text PDFPurpose: To evaluate whether administration of lidocaine into the uterine artery for anesthesia immediately after uterine artery embolization (UAE) with trisacryl gelatin microspheres (TAGM) for leiomyoma is safe and effective.
Materials And Methods: In a single-institution retrospective study, 100 patients underwent UAE using TAGM with a pruned tree endpoint between June 2014 and April 2019. The first 50 patients (control group) underwent UAE without lidocaine; in the second 50 patients (study group), lidocaine was administered into the uterine artery immediately after UAE.