Publications by authors named "Akira Zamma"
Effects of a highly selective acetylcholine-activated K+ channel blocker on experimental atrial fibrillation.
Circ Arrhythm Electrophysiol
February 2011
Article Synopsis
- The study investigates NTC-801, a selective blocker of the acetylcholine-activated K(+) current (I(K,ACh)), as a potential treatment for atrial fibrillation (AF), focusing on its effects on various cardiac ionic currents.
- NTC-801 effectively inhibited I(K,ACh) in atrial cells and reversed shortened action potential durations caused by stimulants, while having no effect on ventricular cells, indicating its atrial specificity.
- In several AF models, NTC-801 showed significant antiarrhythmic effects, prolonging the atrial effective refractory period and converting AF to normal sinus rhythm, highlighting the role of I(K,ACh) in AF development and maintenance.