[Liposome modified with VIP-lipopeptide as a new drug delivery system].

We have designed a novel lipid analog (lipopeptide) that mimics the structural features of modified phospholipids. This lipopeptide is easily synthesized using a peptide synthesizer and has been shown to be useful for the modification of liposomes, which are used as an active targeted drug delivery system (DDS). Vasoactive intestinal peptide (VIP) has high homology with pituitary adenylate cyclase activating peptide (PACAP).

Synthesis of VIP-lipopeptide using a new linker to modify liposomes: towards the development of a drug delivery system for active targeting.

A new component for the solid phase peptide synthesis of lipopeptide, 2-[(4R,5R)-5-({[(9H-fluoren-9-yl)methoxy]carbonylaminomethyl}-2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]acetic acid (2), was designed and synthesized from (-)-2,3-O-isopropylidene-D-threitol (3) in 4 steps. The key step was the selective alkylation of 3 with benzyl bromoacetate in the presence of Cs2CO3. Vasoactive intestinal peptide (VIP)-lipopeptide (1) incorporating this linker was synthesized by solid phase peptide synthesis.

Delayed optical images through coupled-resonator-induced transparency.

We propagated transverse two-dimensional images encoded on optical pulses through a frequency window of a coupled-image-resonator-induced transparency. The optical images are stored and delayed by 10.6ns, reflecting the tunable dispersion of the coupled resonator.

Advanced and delayed images through an image resonator.

We performed optical image propagation experiments in an image resonator consisting of a Fabry-Perot resonator in reflection geometry. Two-dimensional images encoded on optical pulses of 32ns were stored, and either advanced, -6.0ns, or delayed, 10.

[Nonmyeloablative allogeneic peripheral blood stem cell transplantation of renal cell carcinoma].

We presented three cases with refractory metastatic renal cell carcinomas who underwent nonmyeloablative allogeneic peripheral blood stem cell transplantation(PBSCT). A fludarabine and cyclophosphamide-based regimen was used. Complete donor-T-cell chimerism was established at day 94, 40, 52 after PBSCT in each case.