Publications by authors named "Akira Sakaguchi"

In this study, we investigated the effect of biphasic microcurrent electrical stimulation (b-MES) on the epidermal healing process using a rat model of skin abrasion. We analyzed the expression levels of growth factors [fibroblast growth factor 2 (FGF2) and epidermal growth factor (EGF)] and keratin subtypes (K10) in both the b-MES and control groups at different time points after wounding. The b-MES group showed a significantly accelerated healing process of the epithelial tissue, resulting in more consistent healing as compared to the control group.

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Study Design: Retrospective observational study.

Objective: To scrutinize screw motion used in semiconstrained rotational plate systems for anterior cervical discectomy and fusion (ACDF).

Summary Of Background Data: Semiconstrained rotational plate systems are supposed to control graft subsidence and facilitate lordosis acquisition and maintenance by toggling the instrumented vertebrae via variable-angle screws.

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Article Synopsis
  • A 15-year-old girl with a history of hip pain since age 11 presented with ongoing generalized pain, and tests showed no inflammation or rheumatoid factors.
  • She was initially treated with adalimumab (40 mg), resulting in improved disease activity scores, which prompted an increase to 80 mg after 8 months, leading to further improvement.
  • The patient eventually switched to infliximab, demonstrating significant progress over time without negative side effects, highlighting the importance of early TNF inhibitor treatment for juvenile ankylosing spondylitis.
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Background: Castellvi type III and IV lumbosacral transitional vertebrae (LSTVs) are fused to the sacrum. In these cases, the pelvic incidence (PI) and pelvic tilt (PT) may vary according to the selected "S1." This study aimed to determine the optimum vertebral level of these LSTVs when measuring PI and PT.

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Supramolecular nanofibers composed of the closed-ring isomer of a diarylethene formed bundles in a methylcellulose aqueous solution by depletion force while the spheres composed of the open-ring isomer were not coagulated. Upon irradiation with UV light to the suspension of the open-ring isomer, fibers were found to be generated and the formed submillimeter-sized bundles showed a photoinduced shrinking of more than 100 μm under visible light irradiation.

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Photoinduced clustering of polystyrene microbeads and photocontrol of their diffusion was achieved in water with the assistance of photoinduced transformation of supramolecular architecture of amphiphilic diarylethene between sphere and fiber states. When a suspension of polystyrene beads containing the sphere state of diarylethene was UV-irradiated from beneath, clustering of the polystyrene beads by thermal convection was observed. The velocity of clustering was dependent on the amount of photogenerated nanofibers that determines the viscosity of the water.

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We performed maximal exercise tests on 6 men using a bicycle ergometer and then measured the ferric-reducing ability in plasma to clarify the relationship between antioxidant status and exercise intensity. The ferric-reducing ability showed a rectilinear increase with the increase in exercise intensity, whereas the generation of hydroxyl radicals showed a decrease with the increase in exercise intensity. Also, the generation of hydroxyl radicals showed a symmetrical correlation to lactate level in plasma.

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