Synopsis of recent research by authors named "Akira N Shaw"
- Akira N Shaw's recent research primarily focuses on the tumor microenvironment (TME) in relation to the efficacy of CD19-targeted chimeric antigen receptor T-cell (CAR-T) immunotherapy for patients with relapsed/refractory large B-cell lymphoma (LBCL).
- The study utilized advanced methodologies such as NanoString nCounter transcriptome profiling and multiplex immunohistochemistry to analyze pretreatment biopsies, highlighting the importance of factors like PD-L1 expression on macrophages and tumor cells, as well as their proximity to T cells.
- Findings suggest that the composition and arrangement of immune and tumor cells within the TME significantly influence patient responses to CAR-T therapy, offering potential avenues for improving treatment outcomes in LBCL.