Publications by authors named "Akira Higashimori"
Article Synopsis
- A study was conducted to evaluate better bowel preparation methods for patients with constipation, focusing on the effectiveness of 1 L polyethylene glycol plus ascorbic acid combined with either senna or linaclotide before colonoscopy.
- The findings showed that patients who received linaclotide had a significantly lower rate of inadequate bowel preparation (11% vs 20%) and a higher adenoma detection rate (54% vs 45%) compared to those who received senna.
- The results suggest that linaclotide enhances bowel preparation effectiveness without compromising tolerability, making it a promising alternative for constipation patients.
Endoscopic ultrasound-guided antegrade treatment with uncovered self-expanding metal stent for malignant afferent loop syndrome-complicated cholangitis after biliary reconstruction.
Endoscopy
December 2024
Esophageal submucosal hematoma is a rare, often incidental complication of therapeutic endoscopic procedures marked by disrupted blood vessels beneath the esophageal mucosa, forming a hematoma. We report the unique case of a severely thin and alcoholic 38-year-old woman with a history of reflux esophagitis who developed an esophageal submucosal hematoma during an unsedated transnasal endoscopy for health check-up. During the procedure, the patient experienced strong vomiting reflexes and vomited blood, leading to the initial suspicion of either Mallory-Weiss syndrome or epistaxis.
View Article and Find Full Text PDFObjectives: Inadequate bowel preparation (BP) negatively affects the efficacy and quality of colonoscopy. Although constipation has already been reported as one of the most important predictors of inadequate BP, there is limited information on the relation between inadequate BP and bowel habits including constipation-related symptoms, medications, and severity of constipation.
Methods: This single-center, prospective observational study was conducted between August 2019 and May 2020.
Article Synopsis
- Eosinophilic gastrointestinal disorders (EGIDs) are rare but can occur after allogeneic hematopoietic cell transplantation (allo-HCT), particularly when the donor has allergic conditions.
- In a study involving two patients with acute leukemia, both developed food allergies post-cord blood transplantation, leading to eosinophilic esophagitis (EoE) and eosinophilic gastroenteritis (EGE).
- The cases emphasize that unexpected food allergy acquisition after transplantation can lead to EGIDs, particularly in individuals receiving T-cell non-depletion graft-versus-host disease (GVHD) prophylaxis, with non-steroidal dietary treatment proving effective.
Objectives: Low-volume polyethylene glycol plus ascorbic acid (PEG-Asc) reduces the dosage of colonoscopic bowel preparation (BP) solution, but is still poorly tolerated. Adding laxatives to the BP solution reduces the volume of fluid required, without affecting quality. This study aimed to compare 1 L PEG-Asc plus 24 mg senna (1L-PEG/AS) and conventional 2 L PEG-Asc (2L-PEG/A) regimens on BP quality and patient tolerability.
View Article and Find Full Text PDF[Current real-world treatments for Japanese patients with eosinophilic esophagitis].
Nihon Shokakibyo Gakkai Zasshi
October 2022
A total of 306 patients with eosinophilic esophagitis (EoE) were analyzed at our department. Proton pump inhibitors or potassium-competitive acid blockers were used as the first-line treatment in 286 (93.5%) patients.
View Article and Find Full Text PDFArticle Synopsis
- * Out of 389 patients analyzed, the cumulative rebleeding rate was found to be 41.7% over five years, with various factors such as overt OGIB, use of anticoagulants, and previous positive findings influencing the likelihood of rebleeding.
- * The research concluded that rebleeding is a frequent issue in OGIB patients, emphasizing the need for diligent monitoring, particularly for those with liver cirrhosis or histories of significant bleeding.
Background And Aim: Esophageal injury often results in a scar, leading to refractory strictures. The NLRP3 inflammasome activates caspase-1, causing the maturation of interleukin (IL)-1β. Here, we aimed to investigate the preventive effect of pirfenidone (PFD), an antifibrotic drug, on esophageal stricture after ulcer healing and studied its mechanism by focusing on the activation of the NLRP3 inflammasome.
View Article and Find Full Text PDFBackground: Inflammation-based scoring has been reported to be useful for predicting the recurrence and prognosis of various carcinomas. This study retrospectively investigated the relationship between inflammation-based score and intraductal papillary mucinous neoplasms (IPMNs).
Methods: Between January 2013 and October 2018, we enrolled 417 consecutive patients with pancreatic tumors who received surgical resections at our hospital.