Treatment with Ascorbyl Glucoside-Arginine Complex Ameliorates Solar Lentigos.

Little is known about the anti-pigmenting effects of skin-whitening agents on solar lentigos (SLs). To characterize the anti-pigmenting effects of a newly designed derivative ascorbyl glucoside-arginine complex (AGAC) on SLs, lotions with or without 28% AGAC were applied twice daily for 24 weeks in a double-blind half-face study of 27 Japanese females with SLs. The pigmentation scores and skin colors of previously selected SLs on the right and left sides of the faces of the subjects were evaluated using a photo-scale, a color difference meter and a Mexameter.

Depth of Cure of Resin-Based Composites Irradiated With Three Types of Light-Curing Units at Different Output Intensities.

Aim Dental light-curing units (LCUs) are used at Matsumoto Dental University Hospital (MDUH). However, the time of installation of the same type of light irradiator varies, which affects the output intensity of the LCU. The purpose of this study was to evaluate the performance of LCU with different output intensities by comparing the depth of cure (DOC) of resin-based composites (RBCs).

Activities of daily living limitation and functional decline during hospitalization predict 180-day readmission and mortality in older patients with pneumonia: A single-center, retrospective cohort study.

Background: The role of activities of daily living (ADL) as a predictor of adverse outcomes in patients with pneumonia is unclear. This study aimed to assess the association between ADL, including physical and cognitive function, and death or readmission in older inpatients with pneumonia.

Methods: This retrospective, single-center, observational study included consecutive older inpatients with pneumonia between October 2018 and December 2019.

Classification of Patients Based on Dyspnea and Desaturation During Exercise in Interstitial Lung Disease.

Background: Dyspnea and desaturation during exercise are essential assessment items for pulmonary rehabilitation. Characterizing patients using these 2 factors may be important for providing more effective pulmonary rehabilitation. This study aimed to categorize subjects with interstitial lung disease (ILD) using dyspnea and desaturation at the end of the 6-min walk test (6MWT).

Effect of physical frailty on maximum phonation time in community-dwelling older individuals who visited a neurology outpatient clinic.

Background: Maximum phonation time (MPT) is used to assess speech and other oral rehabilitation-related issues. Various factors contribute to MPT decline in older individuals. Although the impact of physical frailty on MPT has been suggested, this has not been conclusively determined.

Wearable Skin Resistance-based Tomographic Sensor for Imaging Contact Pressure Distribution on the Human Body.

This study aims to develop a flexible and thin tactile sensor that can capture the contact pressure distribution on the human body. We, therefore, propose a contact resistance-based tomographic tactile sensor that uses the skin as part of the detector. We first evaluated force sensitivity to show that using the skin as a probing layer is possible.

Influence of Excitation Frequency on the Performance of Peripheral Blood Flow Imaging using Electrical Impedance Tomography.

This paper presents a method for selecting the efficient excitation frequency of Electrical Impedance Tomography (EIT) for imaging peripheral blood flow with high spatial-temporal performance. Using a simulation study, we selected the excitation frequency of 16 kHz to visualize the pulsation of arteries with a high sensitivity. We then conducted a subjective study using 16 electrodes and showed that the conductivity distribution is similar to the anatomical structure of the forearm.

Optimization of electrode positions for equalizing local spatial performance of a tomographic tactile sensor.

A tomographic tactile sensor based on the contact resistance of conductors is a high sensitive pressure distribution imaging method and has advantages on the flexibility and scalability of device. While the addition of internal electrodes improves the sensor's spatial resolution, there still remain variations in resolution that depend on the contact position. In this study, we propose an optimization algorithm for electrode positions that improves entire spatial resolution by compensating for local variations in spatial resolution.

Metabolic and ventilatory changes during postural change from the supine position to the reclining position in bedridden older patients.

The prevention of pneumonia in bedridden older patients is important, and its recurrence in these patients is a relevant issue. Patients who are bedridden and inactive, and have dysphagia are considered to be at risk for pneumonia. Efforts to reduce the bedridden state and low activity may be necessary to reduce the risk of developing pneumonia in bedridden older patients.

Slider Sheet Detection in Charge-Induction Electrostatic Film Actuators.

This work analyzes a built-in slider detection method for a charge-induction type electrostatic film actuator with a high surface-resistance slider. In the detection method, one stator electrode is detached from the parallel driving electrodes and is dedicated to sensing. When a slider with induced charges moves over the sensing electrode, electrostatic induction occurs in the sensing electrode, which causes an electric current.

Therapeutic Effect of Cyclin-Dependent Kinase 4/6 Inhibitor on Dermal Fibrosis in Murine Models of Systemic Sclerosis.

Objective: One of the histologic characteristics of systemic sclerosis (SSc) is an increased number of dermal myofibroblasts, and transforming growth factor β (TGFβ) plays a crucial role in the promotion of myofibroblast differentiation from fibroblasts, leading to dermal fibrosis. This study was undertaken to 1) examine whether inhibition of the cell cycle with a cyclin-dependent kinase 4/6 (CDK4/6) inhibitor suppresses the proliferation of fibroblasts and their differentiation into myofibroblasts, and 2) assess the therapeutic effects of a CDK4/6 inhibitor, administered as monotherapy or in combination with a TGFβ receptor (TGFβR) inhibitor, on dermal fibrosis in murine models of SSc.

Methods: Fibroblasts obtained from the skin of patients with SSc were cultured in the presence or absence of TGFβ.

Chondroprotective effects of CDK4/6 inhibition via enhanced ubiquitin-dependent degradation of JUN in synovial fibroblasts.

Objective: Targeting synovial fibroblasts (SF) using a cyclin-dependent kinase (CDK) 4/6 inhibitor (CDKI) could be a potent therapy for RA via inhibition of proliferation and MMP-3 production. This study was designed to elucidate the mechanism of chondroprotective effects on SFs by CDK 4/6 inhibition.

Methods: CDK4/6 activity was inhibited using CDKI treatment or enhanced by adenoviral gene transduction.

Validity of a novel respiratory rate monitor comprising stretchable strain sensors during a 6-min walking test in patients with chronic pulmonary obstructive disease.

Background: Breathing frequency is rarely measured during a field walking test since the current monitoring system using a face mask is cumbersome for older adults. For effective clinical application, we aimed to validate the new respiratory monitor using wearable strain sensors during a 6-min walk test (6MWT) in young adults and patients with chronic obstructive pulmonary disease (COPD).

Methods: The study included young adults and patients with stable COPD voluntarily recruited from three hospitals.

Impact of physical frailty on the clinical outcomes of older patients hospitalized for pneumonia.

Aim: This study aimed to assess the association between physical frailty and clinical outcomes among older patients hospitalized for pneumonia.

Methods: This study examined 852 consecutive patients hospitalized for pneumonia between October 2018 and September 2020. Patients who were <65 years old, scheduled for admission, did not receive inpatient rehabilitation, or died during admission were excluded.

Reliability and Validity of the Japanese Version of the Barthel Index Dyspnea Among Patients with Respiratory Diseases.

Purpose: Japan has only a few respiratory disease-specific activity of daily living scales that are accepted outside of Japan, and they are not widely used. The Barthel Index dyspnea (BI-d), an improved version of the Barthel Index (BI), may be popular in Japan. The purpose of this study was to develop the Japanese version of BI-d (J-BI-d) and investigate its reliability and validity.

Pressure Stimulus to the Palm Substitutes and Augments Force Sensation.

Studies on pseudo-force feedback have reported that tactile stimuli such as skin stretch and pressure can substitute force sensation. This effect has enabled the design of a compact haptic device. However, little is known about the effect of applying pressure to the palm in terms of force substitution and augmentation, especially regarding how active and passive pressure stimuli differ.

Tomographic Proximity Imaging Using Conductive Sheet for Object Tracking.

This paper proposes a proximity imaging sensor based on a tomographic approach with a low-cost conductive sheet. Particularly, by defining capacitance density, physical proximity information is transformed into electric potential. A novel theoretical model is developed to solve the capacitance density problem using the tomographic approach.

New method for visualizing the dose rate distribution around the Fukushima Daiichi Nuclear Power Plant using artificial neural networks.

This study proposes a new method of visualizing the ambient dose rate distribution using artificial neural networks (ANNs) from airborne radiation monitoring results. The method was applied to the results of the airborne radiation monitoring which was conducted around the Fukushima Daiichi Nuclear Power Plant by an unmanned aerial vehicle. Much of the survey data obtained in the past were used as the training data for building a network.

Translation and Psychometric Analysis of the Japanese Version of the Perceived Maternal Parenting Self-Efficacy Scale.

Objective: To translate the Perceived Maternal Parenting Self-Efficacy (PMP S-E) scale to Japanese and test its psychometric properties among Japanese mothers of low-birth-weight (LBW) infants.

Design: Descriptive psychometric study.

Setting: NICUs in two regional perinatal care centers in the Kinki region of Japan.

Development of Band-shaped Device and Detection Algorithm of Laryngeal Elevation.

This study concerns a measurement device and an algorithm of the laryngeal elevation for the Mendelsohn maneuver. The measurement device is band-shaped and measures the change of the circumferential length of the neck by stretchable strain sensors. The device is lightweight of 35 g.

Measurement of laryngeal elevation time using a flexible surface stretch sensor.

Background: Dysphagia is a growing health problem in aging societies. An observational cohort study targeting community-dwelling populations revealed that 16% of elderly subjects present with dysphagia. There is a need in elderly communities for systematic dysphagia assessment.

Mycosporine-like amino acids stimulate hyaluronan secretion by up-regulating hyaluronan synthase 2 via activation of the p38/MSK1/CREB/c-Fos/AP-1 axis.

Hyaluronan (HA) is an extracellular matrix glycosaminoglycan that critically supports the physicochemical and mechanical properties of the skin. Here, we demonstrate that mycosporine-like amino acids (MAAs), which typically function as UV-absorbing compounds, can stimulate HA secretion from normal human fibroblasts. MAA-stimulated HA secretion was associated with significantly increased and decreased levels of mRNAs encoding HA synthase 2 (HAS2) and the HA-binding protein involved in HA depolymerization (designated HYBID), respectively.