Publications by authors named "Akio Ihaya"

A 76-year-old man with a history of multiple laparotomies and severe coronary artery disease was referred to our hospital after the sudden development of pain and numbness in the lower extremities. Computed tomography showed a thrombosed abdominal aortic aneurysm and diffuse aortic atherosclerosis; compatible with a "shaggy aorta." A good response to thrombolytic therapy permitted elective scheduling of abdominal aortic surgery after coronary artery bypass grafting.

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  • A 34-year-old man with prolonged fever and fatigue was diagnosed with severe bacterial endocarditis affecting his mitral valve, leading to cardiac complications and a bacterial aneurysm in his brain.
  • After emergency surgery for cardiac issues, he was treated with antibiotics while closely monitoring the unruptured aneurysm through imaging.
  • Remarkably, the aneurysm shrank and eventually disappeared within six weeks, suggesting that the combined approach of surgery and medical management was effective in this complex case.
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  • The study explored the effects of the PD-ECGF/TP gene on preventing vein graft failure by inhibiting the migration and proliferation of vascular smooth muscle cells (VSMCs).
  • In the experiment involving 68 female rabbits, a poloxamer hydrogel containing various concentrations of trypsin was used to enhance gene transfer efficiency to the vein grafts before assessing intimal thickness over two time points.
  • Results indicated that the treating with PD-ECGF/TP significantly reduced intimal thickness and VSMC proliferation compared to controls, demonstrating its potential effectiveness in reducing intimal hyperplasia in vascular grafts.
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Background: We previously reported the 2-week benefits of platelet-derived endothelial cell growth factor (PD-ECGF) gene therapy in chronically ischemic myocardium. However, the long-term effects and safety using this gene have not been reported.

Methods: Chronic myocardial ischemia was created in 24 dogs by stenosing the origin of the left anterior descending coronary artery (LAD) using an ameroid constrictor.

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  • PD-ECGF, also known as thymidine phosphorylase, can promote the growth of new blood vessels, potentially benefiting conditions related to chronic limb ischemia, which affects blood flow in the legs.
  • In an experiment on rabbits, researchers injected a gene for PD-ECGF/TP into leg muscles after surgically resecting the femoral arteries, resulting in improved blood pressure and vascular growth in the treatment group compared to control groups.
  • The study concluded that the overexpression of PD-ECGF/TP significantly enhanced blood vessel formation and limb perfusion, suggesting its potential as a therapeutic option for peripheral arterial disease.
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A 65-year-old male with liver metastases after lung cancer resection was treated with five courses of chemotherapy consisting of gemcitabine (GEM) 1,000 mg/m2 (day 1, 8, every 4 weeks) plus carboplatin (CBDCA) AUC 6 (day 1, every 4 weeks). A partial response (PR) was achieved, his symptoms abated and his quality of life(QOL) improved. Although bone marrow suppression was observed as a side effect, it was within the tolerable range and did not interfere with therapy.

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Objective: This study was performed to evaluate the clinical usefulness of the adventitial inversion technique in acute type A aortic dissection, with special attention to the impact of this procedure on the postoperative status of false lumen evaluated by computed tomographic scan.

Methods: From March 2001 to November 2004, 18 consecutive patients underwent emergent surgery for acute type A aortic dissection. Supracoronary graft replacement was performed in all the patients (ascending aorta/hemiarch replacement: 13/18=72%, total arch replacement: 5/18=28%).

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  • The study investigates the effectiveness of chest ultrasonography in detecting pleural adhesions before thoracotomy, since these adhesions can complicate or prevent surgery.
  • A total of 42 patients were evaluated, with ultrasound measuring the pleural movement at various chest wall points to see if they showed restricted sliding, which indicates adhesions.
  • The results indicated that ultrasound was moderately accurate, with varying sensitivity and specificity, suggesting it can help surgeons plan their approach and avoid complications during video-assisted thoracoscopic surgery.
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  • * In lab experiments, VSMCs that overexpressed TP had increased levels of heme oxygenase (HO)-1, which was linked to higher amounts of the cell cycle inhibitor p27(KIP1) and a halt in cell division at the G1 phase.
  • * In live rat studies, introducing TP significantly decreased VSMC migration and neointima formation after vascular injury, indicating that targeting TP could be a potential strategy for treating vascular obstructive diseases.
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Objective: The baseball-diamond principle is generally used for trocar placement during video-assisted thoracic surgery; however, we are unable to treat all peripheral lung lesions using this principle. Therefore, we have developed another method for determining trocar placement based on a modification of the conventional principle. We have termed this method the triangle target principle.

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Platelet-derived endothelial cell growth factor (PD-ECGF), also known as thymidine phosphorylase (TP), has been reported to possess angiogenic activity and to inhibit apoptosis. This study was performed to determine whether PD-ECGF/TP can be used to ameliorate chronic myocardial ischemia. Myocardial ischemia was created in 40 mongrel dogs by placement of an ameroid constrictor on the proximal left anterior descending coronary artery (LAD).

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Mediastinal bronchial artery aneurysm is rare but potentially life-threatening, and requires prompt treatment to avert rupture with catastrophic results. A 78-year-old man was referred to our hospital with a benign esophageal tumor, which appeared as an extrinsic, extramucosal filling defect on an esophagogram. Chest computed tomography and selective bronchial arteriography led to a definitive diagnosis of mediastinal bronchial artery aneurysm.

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  • * TMLR was performed on dogs with blocked coronary arteries, and after two weeks, tissue samples showed that MMP and PA levels were higher in those treated with the laser compared to control groups.
  • * Results indicated that TMLR successfully promoted blood vessel growth and development, linking higher levels of MMPs to increased angiogenesis in the heart tissue.
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