Publications by authors named "Akinyemi J"

Background: Unplanned and rapid urbanization within Nigerian cities with the attendant environmental consequences may hinder achieving malaria elimination goal. Presently, there are limited qualitative studies on malaria case management and care-seeking patterns by settlement type in urban areas in Nigeria. This study, investigated malaria-related health seeking behaviours among different settlement types in Ibadan and Kano metropolises, Nigeria.

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  • The study aimed to investigate how alcohol consumption is linked to stroke occurrences in Nigeria and Ghana by comparing individuals who had strokes to those who didn't.!
  • It involved over 7,368 participants, classifying them into groups based on their alcohol consumption habits, and utilized various statistical models to analyze the data.!
  • Results indicated that current drinkers had a higher risk of stroke, particularly among moderate, binge, and heavy drinkers, while former drinkers showed no significant stroke risk. !
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  • The study developed a prediction model for aminoglycoside-induced ototoxicity (hearing loss) in a cohort of 153 adults undergoing anti-TB treatment with Streptomycin.
  • Key factors influencing the risk of ototoxicity included age, cumulative dosage of Streptomycin, and baseline hearing levels, with age and dosage significantly increasing the risk.
  • The model demonstrated good predictive ability, with training and validation areas under the curve indicating strong discrimination for identifying those at risk for hearing loss.
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Introduction: hypertension is a major public health problem globally. The occurrence has been associated with unhealthy lifestyles (such as high salt consumption, physical inactivity, excessive intake of alcohol and unhealthy diet), which are very critical for hypertension control. The study was conducted to assess the lifestyle practices and their determinants among adults with hypertension in Nigeria.

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  • The study focused on childbearing among women living with HIV in Ibadan, Nigeria, analyzing data from 933 respondents aged 18-49.
  • The findings revealed a total fertility rate of 3.54, with over 70% likely to progress from their first to second birth, but progression rates dropped significantly for second to third births.
  • Various factors influenced birth progression, including initial child count at HIV diagnosis, marital status, education and employment of partners, and knowledge of partner's HIV status.
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Background And Objectives: Prevalence of prediabetes and undiagnosed diabetes are different in rural and urban dwellings, with varying driving factors. This study aimed to determine the differences in risk factors of prediabetes and undiagnosed diabetes among Yoruba speaking adult dwellers in selected rural and urban communities in Nigeria using haemoglobin A1c.

Methods: A cross-sectional study was conducted in five selected states in Southwestern Nigeria.

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Background: Aminoglycosides, such as Streptomycin, are cheap, potent antibiotics widely used Sub-Saharan Africa. However, aminoglycosides are the commonest cause of ototoxicity. The limited prospective epidemiological studies on aminoglycoside ototoxicity from Sub-Saharan Africa motivated this study to provide epidemiological information on Streptomycin-induced ototoxicity, identify risk factors and predictors of ototoxicity.

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Pregnancy termination continues to be a leading cause of maternal morbidity and mortality among young women in Africa. The sub-Saharan Africa region has the highest rate of abortion-related deaths in the world, at 185 maternal deaths per 100,000 abortions. The aim of this study is to investigate the factors associated with pregnancy termination among women aged 15 to 29 years in six sub-Saharan African countries.

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Background: Prediction algorithms/models are viable methods for identifying individuals at high risk of stroke across diverse populations for timely intervention. However, evidence summarizing the performance of these models is limited. This study examined the performance and weaknesses of existing stroke risk-score-prediction models (SRSMs) and whether performance varied by population and region.

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Management of hypertension is challenging in multi-cultural and multi-ethnic sub-Saharan African countries like Nigeria. This diversity calls for multi-dimensional interventional approaches for hypertension control. This study assessed the treatment seeking behaviour and associated factors among adults with high blood pressure from three ethnic groups in Nigeria.

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Background: Hypertension is preeminent among the vascular risk factors for stroke occurrence. The wide gaps in awareness, detection, treatment, and control rates of hypertension are fueling an epidemic of stroke in sub-Saharan Africa.

Purpose: To quantify the contribution of untreated, treated but uncontrolled, and controlled hypertension to stroke occurrence in Ghana and Nigeria.

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  • The study, named Honey Experiment on Leprosy Ulcer (HELP), aims to investigate the effectiveness of raw African honey in healing leprosy ulcers compared to normal saline dressing.
  • Conducted in Nigeria, this trial involves participants receiving either honey or saline treatments and will measure healing outcomes over 84 days.
  • The research will help provide a clear understanding of honey’s potential benefits for ulcer treatment, with the trial actively recruiting participants since March 2022.*
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Background: Rates of cardiovascular (CV) disease mortality is usually higher in men but this equalizes with that of women following menopause.

Objectives: This was to determine the contribution of abdominal obesity and estradiol to cardiovascular risk in postmenopausal women (PMW) as well as estimate their CV risk profile.

Methods: 271 consenting PMW were recruited consecutively into this cross-sectional hospital-based study.

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  • African ancestry populations have the highest stroke burden globally, yet the genetic factors contributing to stroke in these groups are not well understood, prompting the SIREN study in West Africa to investigate this.
  • The study involved recruiting stroke patients and stroke-free controls to conduct a genome-wide association study (GWAS), leading to DNA analysis that identified significant SNPs near specific genes associated with stroke risk.
  • Key findings highlighted protective genetic variants near AADACL2 and MIR5186 on chromosome 3, as well as other notable associations on chromosomes 5, 6, 12, 16, and 18, which could provide insights for future stroke risk assessment in these populations.
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Introduction: the decision of men is pertinent to contraceptive uptake in a patriarchal society like Nigeria. Earlier studies on contraception in Nigeria have focused majorly on women. In this paper, we identified factors influencing contraceptive use, and non-users' perceptions about family planning among Nigerian men.

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Background: Heart failure is now a significant contributor to the burden of non-communicable diseases in developing countries like Nigeria which is experiencing epidemiologic and demographic transition. The epidemiology of heart failure in this country is poorly characterized. The aim of the review is to determine the prevalence of heart failure, the associated risk factors, the aetiology, management, and outcomes of the condition in the country.

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Background: Frequent fruit and vegetable consumption is considered a promising dietary behaviour that protects health. However, most existing studies about the factors associated with this phenomenon among Africans are based on single-country reports, apart from one meta-regression combining smaller studies. This study harmonized large datasets and assessed factors associated with the frequency of fruit and vegetable consumption in this population.

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  • The study explored how diagnosed high blood pressure (HBP) relates to closeness to healthcare and noise sources in Ibadan, Nigeria, focusing on various sociodemographic and economic factors.
  • Researchers analyzed data from 13,531 adults using GIS to map locations of key community facilities and health diagnoses, finding significant links between HBP and proximity to pharmacies, religious institutions, and major roads.
  • The findings revealed that being unemployed, married, and having higher educational levels increased the odds of having diagnosed HBP, suggesting that reducing noise pollution might help lower hypertension rates in urban areas.
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Background: Spontaneous intracerebral hemorrhage (ICH) is associated with a high case fatality rate in resource-limited settings. The independent predictors of poor outcome after ICH in sub-Saharan Africa remains to be characterized in large epidemiological studies. We aimed to determine factors associated with 30-day fatality among West African patients with ICH.

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  • Non-cigarette tobacco (NCT) use is linked to an increased risk of stroke among indigenous Africans, suggesting a need for better understanding and public health interventions.
  • The study involved 7,617 respondents, showing that those who used smokeless NCT had a significant association with stroke, while smoked NCT did not show a strong link.
  • Increased awareness and targeted policies are essential to address the rising burden of stroke related to NCT usage in the population.
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Background: There is a growing interest in stroke genomics and neurobiobanking research in Africa. These raise several ethical issues, such as consent, re-use, data sharing, storage, and incidental result of biological samples. Despite the availability of ethical guidelines developed for research in Africa, there is paucity of information on how the research participants' perspectives could guide the research community on ethical issues in stroke genomics and neurobiobanking research.

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Background: In-person health care poses risks to health workers and patients during pandemics. Remote consultations can mitigate these risks. The REaCH intervention comprised training and mobile data allowance provision for mobile phones to support remotely delivered primary care in Africa compared with no training and mobile data allowance.

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Background: This study aimed to develop a risk-scoring model for hypertension among Africans.

Methods: In this study, 4413 stroke-free controls were used to develop the risk-scoring model for hypertension. Logistic regression models were applied to 13 risk factors.

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Background: Rapid urbanization in Nigerian cities may lead to localized variations in malaria transmission, particularly with a higher burden in informal settlements and slums. However, there is a lack of available data to quantify the variations in transmission risk at the city level and inform the selection of appropriate interventions. To bridge this gap, field studies will be undertaken in Ibadan and Kano, two major Nigerian cities.

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