Ameliorative role of Syzygium aromaticum aqueous extract on synaptosomal tyrosine hydroxylase activity, oxidative stress parameters, and behavioral changes in lead-induced neurotoxicity in mice.

This study reports the protective role of the aqueous extract of Syzygium aromaticum (ESA) against lead (Pb)-induced neurotoxicity in mice. Thirty male mice weighing between 18 g and 25 g were randomly divided into five groups. (1) Group 1 (control group), (2) group 2 (Pb-test group): was administered with a solution containing 0.

Dietary polyphenols mitigate SARS-CoV-2 main protease (Mpro)-Molecular dynamics, molecular mechanics, and density functional theory investigations.

The recent evolution of the SARS-like Coronavirus has ravaged the world. The deadly virus has claimed over millions of lives across the world and hence highlights the need to develop effective therapeutic drugs to contain the disease posed by this parasite. In this study, the inhibitory potential of fifty (50) dietary polyphenols against Coronavirus (SARS-CoV-2) main protease (Mpro) was conducted using the Autodock Vina Molecular docking tool.

Free radical scavenging activity of Telfairia occidentalis extracts and their effects on iron-sulphate induced lipid per oxidation.

Non-enzymic natural antioxidants of plant origin are known to play a key role in inflammation linked with free radicals and oxidative stress. This study investigates the free radical scavenging activity of various Telfairia occidentalis leaves extracts in relation to their inhibitory effects on lipid peroxidation. The extracts markedly exhibited antioxidants activity especially the ethyl acetate (EE) and chloroform (CE) extract which scavenged 1,1-diphenyl-2-picryhydraxyl (DPPH) radicals significantly (p<0.