Publications by authors named "Akinobu Osame"

Article Synopsis
  • The study assessed bleeding risks in COVID-19 patients on extracorporeal membrane oxygenation (ECMO) and evaluated the effectiveness of transcatheter arterial embolization (TAE) for controlling bleeding.
  • Out of 43 patients, 25 bleeding events were recorded, with older age linked to higher risks of bleeding and fatality; those with bleeding had longer hospital stays and higher death rates.
  • TAE was successful in managing bleeding in most cases, highlighting its role in treating elderly patients with COVID-19 experiencing severe complications while on ECMO.
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Background There has been no consensus as to which system, either the Cancer of the Liver Italian Program (CLIP) or the Japan Integrated Staging (JIS) system, is suitable to predict the prognosis of hepatocellular carcinoma (HCC) patients who underwent transcatheter arterial chemoembolization (TACE) as initial therapy. Purpose To retrospectively compare the usefulness of CLIP and JIS in predicting and stratifying the prognosis of HCC patients treated by TACE. Material and Methods Between 1995 and 2005, consecutive 728 patients with untreated HCC who underwent TACE in our institute were selected for this study.

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A 73-year-old female with hepatocellular carcinoma (HCC) received percutaneous transhepatic portal vein embolization (PTPE) before extensive right lobe hepatectomy. Serum levels of des-gamma-carboxy-prothrombin (DCP) were increased and remained at a high level until hepatectomy. Immunohistochemical examination revealed that an increased expression of DCP was demonstrated not only in HCC tissues, but also in the non-cancerous liver of the right lobe, where portal blood flow was blocked off as a result of PTPE.

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Focal fatty change of the segment IV of the liver has been attributed to local systemic venous inflow replacing the portal venous supply, which could develop or be accentuated after gastrectomy. However, focal fatty change due to aberrant pancreaticoduodenal vein that developed after cholecystectomy has never been reported. We report a 30-year-old man with such a rare lesion, which was initially misdiagnosed as a hepatocellular carcinoma, but was confirmed on computed tomography during selective gastroduodenal arteriography.

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Aim: To elucidate whether warming may reduce the viscosity of miriplatin-lipiodol suspension (MPT/LPD) and also the injection pressure through microcatheters, for potential use as a chemotherapeutic agent of transarterial chemoembolization (TACE) for hepatocellular carcinoma (HCC).

Methods: Viscosity of MPT/LPD prepared at on-label dose was measured in vitro at 25°C, 30°C, 40°C, 50°C and 60°C using capillary tube method. Reproducibility of viscosity change was also tested.

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Article Synopsis
  • The study aimed to evaluate the effectiveness of warmed miriplatin-lipiodol suspension (MPT-LPD) as a treatment for hepatocellular carcinoma (HCC) during transarterial chemoembolization (TACE), comparing the results of using it at room temperature versus 40 °C.* -
  • Results indicated that MPT-LPD administered at 40 °C provided a smoother intraarterial appearance and significantly improved local therapeutic effects on HCC, as reflected in follow-up CT scans, compared to the room temperature group.* -
  • The study concluded that warmed MPT-LPD showed better flow within blood vessels and higher treatment effectiveness short-term, suggesting potential advantages of heating the solution before administration during TACE.*
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Bleeding from varices arising from outside of the gastroesophageal region is rare. We report a case of ruptured jejunal varices, successfully treated with B-RTO. Our patient was a 60-year-old man with alcoholic cirrhosis who had undergone total gastrectomy two years before he visited our clinic with tarry stool and hypotensive shock.

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A 60-year-old woman who had had a history of renal cell carcinoma with intraperitoneal recurrence presented with multiple liver masses. Computed tomography demonstrated multiple enhancing lesions in the both lobes of the liver, and there was an apparent small vessel coursing within one of the lesions. On magnetic resonance imaging, masses showed slight T1 and T2 prolongation, and restricted diffusion: On the hepatobiliary phase of liver-specific contrast agent enhancement, lesions were shown as low signal intensity of varying degree.

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Pancreaticoduodenectomy (PD) with preservation of the arcade in the head of the pancreas was performed in a 73-year-old male with ampullary adenocarcinoma associated with occlusion of the common hepatic artery (CHA) in another hospital. He developed active bleeding from his drain site, at 18 days after the operation. He was transferred to our hospital for emergent embolization.

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