Synopsis of recent research by authors named "Akinobu Maeda"
- Akinobu Maeda's research primarily focuses on the role of the angiotensin II type 1 receptor (AT1R) and its associated proteins, particularly ATRAP, in the regulation of kidney function, metabolism, and hypertension, highlighting their potential impact on age-related renal changes and obesity-related metabolic disorders.
- Studies demonstrate that ATRAP can inhibit pathological activation of the renin-angiotensin system (RAS), revealing its importance in promoting AT1R internalization and affecting both adipocyte function and renal sodium reabsorption in various metabolic conditions.
- Maeda has also explored the therapeutic effects of specific angiotensin receptor blockers and oriental herbal medicines (such as Bofu-tsusho-san), showing promising results in modulating blood pressure and metabolic profiles in mouse models and hypertensive patients, suggesting integrative approaches could be beneficial in treating obesity-related hypertension.
