Immunomodulator adherence in multiple myeloma patients with lower socioeconomic status: a retrospective study.

Objective: Poor adherence to oral chemotherapy adversely impacts clinical outcomes and escalates overall healthcare costs. Despite barriers to medication adherence, a significant gap remains in assessing adherence to oral chemotherapy among multiple myeloma (MM) patients with lower socioeconomic status. Hence, our study aims to evaluate immunomodulator adherence in MM patients at a county hospital, primarily serving underrepresented and indigent individuals with low socioeconomic status across the greater Houston area.

Trace elements concentrations in soil contaminate corn in the vicinity of a cement-manufacturing plant: potential health implications.

Background: Cultivated lands in the vicinity of industry are vulnerable due to trace element releases from industrial activities. One such situation concerns the surrounding of the largest cement-manufacturing plant in sub-Saharan Africa, located in Obajana, Nigeria.

Objective: This study aimed at examining the trace element concentrations in the soil as they contaminate corn crops in the vicinity of a cement manufacturing plant.

Seed at the Interface of Food and Medicine: Effect of Extracts on Some Reproductive Parameters, Hepatic and Renal Histology.

The lipid-rich Seed of has been promoted as an effective water clarifier. Aside its vital nutritional application as an emerging food additive, the seed has continued to gain a wider acceptance in various global ethnomedicines for managing several communicable and lifestyle diseases, howbeit, its potential toxic effect, particularly on fertility and pregnancy outcomes has remained uninvestigated; the effect of seed (MOSE) aqueous-methanol extracts on fertility and pregnancy outcome, was investigated using female Wistar rats that were divided into 50, 100, 300 and 500 mg per kilogram body weight. Group six was given seed treated water ( group).

Fast neutron activation of ubiquitous materials.

Nuclear explosions expose ubiquitous materials to large numbers of neutrons, producing a variety of radioactive isotopes. To simulate such phenomena from both fission and thermonuclear explosions, we irradiated 29 different targets with approximately 3 and 14 MeV neutrons and measured the beta-delayed gamma rays using germanium detectors. For each neutron energy, the expected radioisotopes, half-lives, and gamma ray energies were deduced.

Protective role of (onion) juice on maternal dexamethasone induced alterations in reproductive functions of female offspring of Wistar rats.

Maternal treatment with dexamethasone induces oxidative stress in the reproductive structures of offspring. Consumption of improves antioxidant status. This study was designed to evaluate the protective role of juice on maternal dexamethasone induced alterations in reproductive functions of the female offspring of Wistar rats.

Cancer Disparities and Black American Representation in Clinical Trials Leading to the Approval of Oral Chemotherapy Drugs in the United States Between 2009 and 2019.

Purpose: Over the past 10 years, oral chemotherapy made up about half (45.6%) of all US Food and Drug Administration (FDA)-approved oncolytic and hematologic medications. Given the disparity in incidence and mortality rate because of certain cancers among Black Americans (BAs) in the United States, a review of BA's representation in the clinical trials that lead to the development and FDA approval of oral chemotherapy drugs becomes imperative.

Evaluation of long-term dermal exposure to soil contaminated with spent engine oil in male Wistar rats: An experimental approach.

Continuous occupational exposure to spent engine oil (SEO) poses physiological risks to humans, especially to automobile mechanics. This study investigated the physiological effects of SEO-contaminated soil in a male Wistar rat model. Animals were dermally exposed to soil contaminated with SEO for 120 consecutive days and compared with rats exposed to uncontaminated soil (negative control).

Saccharum officinarum juice alters reproductive functions in male Wistar rats.

Infertility is a problem across almost all cultures and societies. Problems in the male partner, especially as a result of unhealthy dietary habits, are the commonest single group of course. Many populations, therefore, tend more toward the use of natural dietary substitutes opined to proffer less risk to reproductive functions and more health benefits.

juice protect against alterations in reproductive functions induced by maternal dexamethsone treatment during lactation in male offspring of Wistar rats.

Treatment with dams with dexamethasone during lactation has been reported to induce oxidative stress in the testis of the offspring. (Red Onion) is known to be a potent free radical scavenger. The protective role of against oxidative stress induced in testis following treatment with dexamehasone during lactation in Wistar rats was assessed.

Saccharum officinarum molasses adversely alters reproductive functions in male wistar rats.

The widely reported anti-androgenic effects of refined sugar led to the exploration of safer alternatives. molasses (SOM), a byproduct of sugar processing is gaining popularity as a substitute. This study investigated the effects of SOM and compared them to those of refined sugar on male reproductive functions.

Limb length discrepancy and gait parameters of amateur football players in Lagos State, Nigeria.

Background: Football is a widely played sport globally. Limb length discrepancies have been found to be common among football players and these may lead to abnormal gait.

Objectives: The purpose of this study was to determine the relationship between limb length discrepancy (LLD) and gait parameters of amateur football players in Lagos State, Nigeria.

Low-Energy Physics Reach of Xenon Detectors for Nuclear-Recoil-Based Dark Matter and Neutrino Experiments.

Dual-phase xenon detectors lead the search for keV-scale nuclear recoil signals expected from the scattering of weakly interacting massive particle (WIMP) dark matter, and can potentially be used to study the coherent nuclear scattering of MeV-scale neutrinos. New capabilities of such experiments can be enabled by extending their nuclear recoil searches down to the lowest measurable energy. The response of the liquid xenon target medium to nuclear recoils, however, is not well characterized below a few keV, leading to large uncertainties in projected sensitivities.

Coconut Water Prevents Renal and Hepatic Changes in Offspring of Monosodium Glutamate-Treated Wistar Rat Dams.

Monosodium glutamate (MSG) is a widely-consumed taste enhancer which has been implicated in the aetiology of renal and hepatic dysfunction in adults and their offspring. There is increasing evidence on the therapeutic properties of Coconut Water (CW) in kidney and liver disorders. This study investigated the effects of CW on renal and hepatic functions in offspring of MSG-fed dams.

Protective action of N-acetylcysteine on sperm quality in cyclophosphamide-induced testicular toxicity in male Wistar rats.

Background: Reductions in sperm quality due to free radical formation during cancer chemotherapy are well documented, hence the need for an adjunct antioxidant treatment during chemotherapy. This study was designed to investigate the effects of N-acetylcysteine on sperm quality following cyclophosphamide exposure in male Wistar rats.

Methods: wenty male Wistar rats weighing 150-170g were randomly assigned into 4 groups of five rats each, and were orally administered distilled water (Control), Cyclophosphamide (6mg/kg), N-acetylcysteine (100mg/kg) or Cyclophosphamide + N-acetylcysteine for 21 days.

Cocos nucifera water improves metabolic functions in offspring of high fat diet fed Wistar rats.

Background: Maternal high fat diet has been implicated in the aetiology of metabolic diseases in their offspring. The hypolipidaemic actions of Cocos nucifera water improve metabolic indices of dams consuming a high fat diet during gestation. This study investigated the effects of C.

Changes in kidney function and oxidative stress biomarkers in offspring from dams treated with dexamethasone during lactation in Wistar rats.

Background: The effects of maternal exposure to glucocorticoids during gestation on various organs in the offspring have been reported in literature. There is paucity of information on the effects of maternal glucocorticoids treatment during lactation on organ functions in the offspring. The present study was designed to investigate the changes in kidney function and oxidative stress biomarkers in offspring of dams treated with dexamethasone during lactation in Wistar rats METHODS: Twenty pregnant rats (180-200g) were divided into 4 groups (n=5).

Effects of methotrexate on serum testosterone level in sleep deprived male Wistar rats.

Background: Sleep deprivation has been reported to decrease testosterone levels but the mechanism remains unclear. Studies have shown that sleep deprivation increases interleukin 1 beta (IL-1β), a pro-inflammatory cytokine and that increased IL-1β levels cause reductions in Leydig cell production of testosterone. This study was therefore designed to determine the effects of methotrexate, an IL-1β blocker on serum testosterone levels in sleep deprived male Wistar rats.

Coconut water alters maternal high fat diet induced changes in hormones and pup morphometry of Wistar rats.

Background: Maternal high fat diet (HFD) during gestation adversely programmes foetal metabolism and cardiovascular function for the development of obesity and its related cardiovascular diseases in adult life. The hypolipidemic actions of coconut water (CW) in the presence of HFD have been reported. This study examined the effects of oral administration of CW on lipid panel, hormone profile, pup and placental morphometry of dams fed HFD during gestation.

Maternal treatment with dexamethasone during lactation delays male puberty and disrupts reproductive functions via hypothalamic-pituitary-gonadal axis alterations.

The effects of maternal treatment with dexamethasone during lactation on pubertal timing, serum hormonal profile and sperm indices in the male offspring were assessed. Twenty lactating dams were divided into 4 groups (n=5). Group 1 was administered subcutaneously 0.

Comparative evaluation of the aphrodisiac efficacy of sildenafil and Carpolobia lutea root extract in male rabbits.

Aims: In spite of the folkloric use of the root of Carpolobia lutea as a sexual stimulant in man, there has been limited scientific proof of its efficacy. This study compares the efficacy of methanol extract of C. lutea root (MECLR) and sildenafil on the sexual activity of male rabbits.

Maternal hyperglycemia at different stages of gestation and its effects on male reproductive functions in rats.

The critical period during which maternal hyperglycemia predisposes offspring to develop reproductive disorders in adult life is not known. The relationship between maternal hyperglycemia at different stages and reproductive functions of male offspring was investigated. A single intraperitoneal injection of alloxan (90 mg/kg body weight) was administered at gestation days (GD) 1, 8 and 15.

Cocos nucifera L. water improves reproductive indices in Wistar Rats.

Background: This study explored the effects of Cocos nucifera L. water (CW) on the hypothalamo-pituitary-gonadal axis (HPG) and fertility in Wistar rats.

Methods: Adult male and female Wistar rats were treated orally as follows; Study 1: Group 1: control (distilled water), group 2: 20 ml/kg corn oil (danazol vehicle), group 3: 20 ml/kg CW, group 4: 40 ml/kg CW, group 5: danazol, group 6: danazol + 20 ml/kg CW and group 7: danazol + 40 ml/kg CW.

Effects of vitamin E and melatonin on serum testosterone level in sleep deprived Wistar rats.

Background: Sleep deprivation affects a significant proportion of the global population. It has been reported to induce oxidative stress in the testes and reduce serum testosterone levels. Exogenous anti-oxidants have been known to prevent damages and diseases associated with oxidative stress but there is dearth of knowledge on their effectiveness during sleep deprivation.