Desflurane anaesthesia increases sister chromatid exchanges in human lymphocytes.

Background: We investigated genotoxic effects of desflurane on the frequency of sister chromatid exchange (SCE) in peripheral blood lymphocytes of patients during and after anaesthesia.

Methods: Fifteen female patients, ASA classification I-II, aged 26-54 years, undergoing elective surgery were enroled in this study. Anaesthesia was induced by injection of thiopental 5-7 mg/kg and fentanyl 1 microg/kg.

Propofol and propofol-ketamine in pediatric patients undergoing cardiac catheterization.

We investigated the effects of propofol and propofol-ketamine on hemodynamics, sedation level, and recovery period in pediatric patients undergoing cardiac catheterization. We performed a prospective, randomized, double-blind study. The study included 60 American Society of Anesthesiologists physical status II or III (age range, 1 month-13 years) undergoing cardiac catheterization for evaluation of congenital heart disease.

Single-dose dexmedetomidine reduces agitation and provides smooth extubation after pediatric adenotonsillectomy.

Background: Dexmedetomidine has shown sedative, analgesic, and anxiolytic effects after intravenous (IV) administration. Sevoflurane is associated with a high incidence of emergence agitation in preschool children. In this placebo-controlled study, we examined the effect of single dose dexmedetomidine on emergence agitation in children undergoing adenotonsillectomy.

Single-dose dexmedetomidine attenuates airway and circulatory reflexes during extubation.

Background: The alpha agonist dexmedetomidine, a sedative and analgesic, reduces heart rate and blood pressure dose-dependently. We investigated whether it also has the ability to attenuate airway and circulatory reflexes during emergence from anaesthesia.

Methods: Sixty ASA I-III patients received a standard anaesthetic.

Obstructive airway diseases in women exposed to biomass smoke.

The majority of women living in rural areas in Turkey use biomass fuels for domestic energy and are exposed to high levels of indoor air pollution every day. The objective of this study was to compare the presence of chronic airway diseases (CAD) in two groups of nonsmoking women older than 40 years with (exposed group, n=397) and without a history of exposure to biomass cooking (liquid petroleum gas (LPG); control group, n=199), in 2002 in Kirikkale, Turkey. Detailed respiratory symptoms were collected with a standard questionnaire adapted from that of the British Medical Research Council.

Ketamine reduces lidocaine-induced seizures in mice.

Systemic toxic reactions to local anesthetics are brought about by absolute overdosage, and, most commonly, inadvertent intravascular injections. The anti-convulsant action of ketamine has been studied. However, the effect of ketamine on lidocaine-induced convulsions has not been reported.

Irritable bowel syndrome in young and elderly patients with stable asthma.

Background: It has been speculated that asthma and irritable bowel syndrome may share common pathophysiological processes.

Aim: To estimate the prevalence of irritable bowel syndrome in young and elderly patients with stable asthma.

Patients And Methods: Sixty-five young (age < 60 years) and 66 elderly (age > or = 60 years) stable asthmatics, and 119 age-matched healthy volunteers were enrolled.

Addition of dexmedetomidine to lidocaine for intravenous regional anaesthesia.

Background And Objective: The aim of this study was to determine the duration of onset and regression time of sensory and motor blocks, the quality of anaesthesia and postoperative analgesia by the addition of dexmedetomidine to local anaesthetic solution in intravenous regional anaesthesia (IVRA).

Methods: Forty patients scheduled for elective hand surgery participated in this prospective randomized double-blind study. The IVRA was achieved using 3 mg kg(-1) lidocaine diluted with saline to a total volume of 40 mL in the control group or 1 microg kg(-1) of dexmedetomidine + 3 mg kg(-1) lidocaine diluted with saline to a total volume of 40 mL in the dexmedetomidine group.

Comparison of propofol with propofol-ketamine combination in pediatric patients undergoing auditory brainstem response testing.

Objective: The aim of our study was to compare propofol with propofol-ketamine combination for sedation and also to compare related complications in children undergoing auditory brainstem response (ABR) testing.

Methods: Sixty ASA I-II patients aged between 1 and 13 years of age were sedated for ABR testing. Propofol 1.

A comparison of fentanyl-propofol with a ketamine-propofol combination for sedation during endometrial biopsy.

Study Objective: The purpose of this study was to compare the clinical activities of ketamine and fentanyl when used in combination with propofol for outpatients undergoing endometrial biopsy. The investigated parameters were respiration, sedation, recovery rate, side effects, time to discharge, and patient satisfaction.

Design: Prospective, randomized, double-blind study.

Modelling of calcium dynamics in brain energy metabolism and Alzheimer's disease.

Functional imaging techniques play a major role in the study of brain activation by monitoring the changes in blood flow and energy metabolism. In order to interpret functional neuroimaging data better, the existing mathematical models describing the links that may exist between electrical activity, energy metabolism and hemodynamics in literature are thoroughly analyzed for their advantages and disadvantages in terms of their prediction of available experimental data. Then, these models are combined within a single model that includes membrane ionic currents, glycolysis, mitochondrial activity, exchanges through the blood-brain barrier, as well as brain hemodynamics.

Spectral analysis of event-related hemodynamic responses in functional near infrared spectroscopy.

The goal of this paper is to design experiments that confirm the evidence of cognitive responses in functional near infrared spectroscopy and to establish relevant spectral subbands. Hemodynamic responses of brain during single-event trials in an odd-ball experiment are measured by functional near infrared spectroscopy method. The frequency axis is partitioned into subbands by clustering the time-frequency power spectrum profiles of the brain responses.

The role and influence of stakeholders and donors on reproductive health services in Turkey: a critical review.

Since 1965, Turkey has followed on anti-natalist population policy and made significant progress in improving sexual and reproductive health. This paper presents a critical review of the national reproductive health policies and programmes of Turkey and discusses the influence of national and international stakeholders and donors on policy and implementation. While government health services have played the primary role in meeting sexual and reproductive health needs, international donor agencies and national non-governmental and other civil society organisations, especially universities, have played an important complementary role.

When to inject analgesic agents intra-articularly in anterior cruciate ligament reconstruction: before or after tourniquet releasing.

Purpose: To evaluate 2 different applications of an intra-articular (IA) mixture composed of 40 mL 0.25% bupivacaine and 2 mg morphine in anterior cruciate ligament (ACL) reconstructions, before and after tourniquet release.

Type Of Study: Prospective, double-blind, randomized, clinical trial.

Results and lessons learned from a small medical abortion clinical study in Turkey.

This article presents results from a small, introductory clinical study offering a simplified regimen medical abortion to women in Turkey. A total of 208 women from five sites were recruited from July 2000 through March 2001. All eligible consenting women were given 200 mg oral mifepristone at the clinic followed by 400 microg oral misoprostol 2 days later either at home or at the clinic.

A new treatment modality for fibromyalgia syndrome: hyperbaric oxygen therapy.

Fibromyalgia syndrome (FMS) is characterized by longstanding multifocal pain with generalized allodynia/hyperalgesia. There are several treatment methods but none has been specifically approved for this application. We conducted a randomized controlled study to evaluate the effect of hyperbaric oxygen (HBO) therapy in FMS (HBO group: n = 26; control group: n = 24).

Cervical and lumbar spinal changes diagnosed in four-view radiographs of 732 military pilots.

Background: Pilots who fly jet fighters or helicopters frequently experience vertebral problems due to acceleration and vibration, wearing helmets and other headgear, and sitting in suboptimal postures.

Methods: We looked for spondylarthritic or spondylitic changes in 4-view radiographs (AP, lateral, left and right oblique) of the cervical and lumbar vertebrae of 732 pilots and 202 non-flying controls. The subjects included 91 F-16 jet pilots, 363 other jet pilots, 119 transport pilots, and 159 helicopter pilots.

Selective serotonin reuptake inhibitors in pilot fatalities of civil aviation accidents, 1990-2001.

Introduction: Selective serotonin reuptake inhibitors (SSRIs) are popularly prescribed for treating depression. With a few exceptions, these psychotropic medications are not approved by aeromedical regulatory authorities for use by aviators. Since SSRIs have the potential for impairing performance and causing drug-drug interactions, the prevalence of SSRIs in pilot fatalities of civil aviation accidents was evaluated.

Chiari-I malformation in two fighter pilots.

This report describes two cases of Chiari Malformation Type I (Chiari-I) in fighter pilots of the Turkish Air Force. Chiari-I is a congenital malformation characterized by herniation of cerebellar tonsils through the foramen magnum. Patients have symptoms and signs related to dysfunction of the brainstem, spinal cord, and cerebellum.

Non-invasive gastric motility monitor: fast electrogastrogram (fEGG).

We propose a new analysis method to extract the motility information from the electrogastrogram signal that has been recorded at a higher sampler rate than the conventional approaches. This technique utilizes a fourth order Butterworth bandpass filter in extracting the 50-80 cycles per minute (cpm) activity that was previously noted to represent the spike activity range of the cutaneous signals of dogs. Receiver operating characteristics (ROC) analyses have been applied to the processed data to compare the detection performance of our fEGG technique to the conventional approaches that use the slow wave as the reference.

Nucleocapsid protein gene sequence analysis reveals close genomic relationship between turkey coronavirus and avian infectious bronchitis virus.

Antibodies to infectious bronchitis virus (IBV) cross-react with turkey coronavirus (TCV) in immunofluorescence assay (IFA) indicating that IBV and TCV may share an amino acid sequence similarity. To determine its extent, the gene encoding the nucleocapsid (N) protein of TCV was amplified by reverse transcription-PCR (RT-PCR) from RNA purified from intestines of embryos of turkeys infected with various TCV isolates and from allantoic fluid of chicken embryos infected with IBV M41 strain, the obtained N genes were cloned, sequenced and compared with known sequences of N genes of five IBV strains. The primers for amplification were designed from the genome of IBV PCR products were obtained only from two of eight TCV isolates tested.