Publications by authors named "Akimi Kawai"
Article Synopsis
- Researchers studied the immune response in 109 patients with plasma cell dyscrasia (PCD) after receiving two or three doses of the SARS-CoV-2 mRNA vaccine, focusing on the production of antibodies and immune cells.
- The results indicated that while ongoing anti-myeloma treatments negatively affected antibody production, booster dose (Dose 3) significantly improved antibody levels and the number of patients achieving adequate immune response.
- The study underscored the importance of the booster vaccine for enhancing both humoral (antibody) and cellular immune responses in PCD patients, noting specific drug classes that had varying impacts on vaccine effectiveness.
Article Synopsis
- This study evaluated the immune response to SARS-CoV-2 mRNA vaccines in 165 lymphoma patients, focusing on their antibody levels after the second and third doses.
- Results showed that after the second dose, 56% had adequate antibody responses, while 28% were non-responders, influenced by factors like timing of vaccination after chemotherapy and lymphocyte count.
- After the third dose, there was a notable increase in antibody levels, with 26% of previous non-responders achieving seroconversion, indicating that additional vaccine doses can improve immune responses in immunocompromised individuals.
J Clin Med Res
March 2022
Article Synopsis
- - Chronic inflammation from conditions like Crohn's disease can cause harmful mutations in hematopoietic stem cells, potentially leading to leukemia.
- - A case study highlighted a patient who developed acute promyelocytic leukemia (APL) at 51 after living with chronic Crohn's disease since age 28, despite receiving some treatments.
- - The findings suggest that ongoing inflammation in Crohn's disease may increase the risk of genomic instability in stem cells, making APL a serious concern for these patients.
