Publications by authors named "Akimasa Kimura"

Background: Modular stems are useful for total hip arthroplasty (THA) in anatomically difficult dysplasia. Here, we present mean 6.8-year outcomes of cementless primary THA using S-ROM-A (modified modular stem for Asian patients) femoral prosthesis in anatomically difficult cases.

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Background: There have been several reports regarding airport security checks using arched metal detectors in patients with orthopedic implants and/or joint replacement surgery. Implants of different sizes and/or materials are used in total hip arthroplasty (THA), but there have been no reports regarding differences in detection rates between different types of THA implants and materials. We examined detection rates by airport metal detectors among THA patients with different implants.

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Background: The difference in clinical results between the direct anterior approach (DAA) and the anterolateral approach (ALA) for total hip arthroplasty (THA) is still unclear. The purpose of this study was to compare clinical results, including nerve injuries, between DAA and ALA in one-stage bilateral THA in a prospective, randomized controlled trial.

Methods: Thirty patients were recruited for primary bilateral THAs from 2014 to 2016.

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Article Synopsis
  • Traumatic brain injury (TBI) leads to significant brain damage, disability, and disruption of the blood-brain barrier (BBB), which contributes to complications like brain edema and neuroinflammation.
  • In a mouse study using lateral fluid percussion injury (FPI), researchers found that the endothelin-1 (ET-1) and its receptors increased after TBI, which correlated with worsening BBB dysfunction and brain edema.
  • Administering the endothelin antagonist BQ788 improved recovery from these effects by reversing the damage to BBB-protective proteins and reducing the presence of inflammatory astrocytes.
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Brain edema is a potentially fatal pathological state that often occurs after brain injuries such as ischemia and trauma. However, therapeutic agents that fundamentally treat brain edema have not yet been established. We previously found that endothelin ETB receptor antagonists attenuate the formation and maintenance of vasogenic brain edema after cold injury in mice.

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