Prospective study of a venom batch (Bj2015) - phospholipase A activity, immunogenicity, neurotoxicity, and myotoxicity parameters.

venom's (Bj2015) batch was biomonitored quarterly for one year to assess phospholipase A (PLA) activity, immunogenicity, neurotoxicity, and myotoxicity. models were applied to evaluate losses using decay model and recoveries by predictive trend analysis. Mice were immunized with Bj2015.

New pharmacological insights of .

leaves are popularly used against snakebites in Brazil. The hydroethanolic extract from aerial parts of (HEGg) was assayed against the neurotoxicity and myotoxicity induced by venom. A traditional myographic technique was applied for neurotoxicity and the resulting muscles were treated routinely by light microscopy analysis for myotoxicity.

Pharmacological Properties of (Vochysiaceae) Extract to Neutralize the Neuromuscular Blockade Induced by Bothropstoxin-I (Lys49 Phospholipase A) Myotoxin.

Bothrops snakes are responsible for more than 70 % of snakebites every year in Brazil and their venoms cause severe local and systemic damages. The pharmacological properties of medicinal plants have been widely investigated in order to discover new alternative treatments for different classes of diseases including neglected tropical diseases as envenomation by snakebites. In this work, we have investigated the ability of Vochysia haenkeana stem barks extract (VhE) to neutralize the neuromuscular effects caused by Bothropstoxin-I (BthTX-I), the major phospholipase A (PLA) myotoxin from B.