Publications by authors named "Akil Awad"
Article Synopsis
- The study investigates the survival rates of out-of-hospital cardiac arrest (OHCA) patients with shockable rhythms in relation to the number of defibrillations they received.
- It analyzed data from 10,549 patients in Sweden over a decade, finding that survival rates decreased significantly with each additional defibrillation.
- The results indicate that patients receiving more shocks had lower 30-day survival probabilities, suggesting that after a certain point, additional defibrillations may not be beneficial.
Article Synopsis
- Brain injury is the main cause of death after cardiac arrest and leads to severe disabilities in survivors, impacting patients, families, and society.
- This study aimed to investigate the relationship between neurologic recovery at hospital discharge and long-term survival, comparing patients with complete recovery to those with varying levels of disabilities.
- An analysis of 9,390 cardiac arrest survivors showed that 78.5% achieved complete recovery, and those with complete recovery had a significantly higher 5-year survival rate (73.8%) compared to those with moderate (64.7%) and severe disabilities (54.2%).
Article Synopsis
- The PRINCESS2-study aims to evaluate the effectiveness of ultrafast hypothermia (cooling initiated during or immediately after cardiac arrest) on neurologic recovery in patients who have suffered out-of-hospital cardiac arrest with shockable rhythms, compared to standard care without early cooling.
- The trial will involve randomly assigning 1022 patients to either receive trans-nasal cooling shortly after arrival of emergency medical services, followed by in-hospital hypothermia, or to receive standard care without cooling.
- The primary outcome measured will be survival with complete neurologic recovery at 90 days, with secondary outcomes including overall survival rates at hospital discharge and 90 days, and neurologic recovery scores.*
In animal models, early initiation of therapeutic cooling, intra-arrest, or restored circulation has been shown to be neuroprotective shortly after cardiac arrest. We aimed to assess the feasibility and cooling efficacy of transnasal evaporative cooling, initiated as early as possible after hospital arrival in patients randomized to cooling in the TTM2 trial. This study took the form of a single-center (Södersjukhuset, Stockholm) substudy of the TTM2 trial (NCT02908308) comparing target temperature management (TTM) to 33 °C versus normothermia in OHCA.
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- This study looked at how too much oxygen (hyperoxemia) affects survival after patients have a heart attack and are revived.
- Researchers analyzed data from almost 10,000 patients admitted to intensive care in Sweden, separating them into groups based on their oxygen levels.
- They found that people with hyperoxemia had worse chances of surviving 30 days compared to those with normal oxygen levels, especially as the oxygen levels increased.
Background: Targeted temperature management is recommended for patients after cardiac arrest, but the supporting evidence is of low certainty.
Methods: In an open-label trial with blinded assessment of outcomes, we randomly assigned 1900 adults with coma who had had an out-of-hospital cardiac arrest of presumed cardiac or unknown cause to undergo targeted hypothermia at 33°C, followed by controlled rewarming, or targeted normothermia with early treatment of fever (body temperature, ≥37.8°C).
Purpose: To study the association between early initiation of intra-arrest therapeutic hypothermia and neurologic outcome in out-of-hospital cardiac arrest.
Methods: A prespecified sub-analysis of the PRINCESS trial (NCT01400373) that randomized 677 bystander-witnessed cardiac arrests to transnasal evaporative intra-arrest cooling initiated by emergency medical services or cooling started after hospital arrival. Early cooling (intervention) was defined as intra-arrest cooling initiated < 20 min from collapse (i.
Aim: There are limited data on long-term outcome in out-of-hospital cardiac arrest patients following the treatment shift of target temperature management (TTM) from 33 °C to 36 °C outside the controlled settings of randomised trials. The aim of this study was to evaluate the adherence to TTM guidelines after the publication of the TTM trial and if the change in temperature level influence six-month survival.
Methods: OHCA patients admitted to intensive care units (ICU) and recorded in the Swedish Intensive Care Registry (January 2010-March 2016) were included.
Background: Renal dysfunction after acute kidney injury (AKI) is common, potentially modifiable, but poorly understood. Acute kidney disease (AKD) describes renal dysfunction 7 to 90 days after AKI and is determined by percentage change in creatinine from baseline. Chronic kidney disease (CKD) is defined as the estimated glomerular filtration rate (eGFR) less than 60 ml/min/1.
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