An Online Survey Testing Factorial Invariance of the Optimization in Primary and Secondary Control Scales among Older Couples in Japan and the US.

This study examines the factorial invariance of the Optimization in Primary and Secondary Control (OPS) scale and its associations with subjective well-being among older couples in Japan and the US. To this end, 200 older couples in Japan and 220 in the US were recruited through paid vendors and completed the questionnaire online. Couples were eligible if husbands were 70 years or older and wives were 60 years or older.

Up-regulation of CAR expression through Elk-1 in HepG2 and SW480 cells by serum starvation stress.

Constitutive androstane receptor (CAR) is a transcription factor regulating the expression of several genes related to drug metabolism. CAR expression was elevated in human HepG2 and SW480 cells by serum starvation. From reporter gene assays, mutagenesis, RNA interference, and chromatin immunoprecipitation assays, we identified the serum response element at -142/-139 in the CAR gene transactivated by Elk-1.

Expression of CAR in SW480 and HepG2 cells during G1 is associated with cell proliferation.

Constitutive androstane receptor (CAR) is a transcription factor to regulate the expression of several genes related to drug-metabolism. Here, we demonstrate that CAR protein accumulates during G1 in human SW480 and HepG2 cells. After the G1/S phase transition, CAR protein levels decreased, and CAR was hardly detected in cells by the late M phase.