Publications by authors named "Akiko Takano"
Exercise training ameliorates carbon tetrachloride-induced liver fibrosis and anxiety-like behaviors.
Am J Physiol Gastrointest Liver Physiol
December 2024
Article Synopsis
- Chronic liver diseases, including cirrhosis, are linked with mood disorders like anxiety, and this study investigates how regular exercise can impact these anxiety-like behaviors in mice with liver fibrosis.
- The research involved male C57/BL6 mice subjected to liver fibrosis through carbon tetrachloride (CCl) and tested the anxiolytic effects of voluntary exercise using an elevated plus maze for assessment.
- Findings indicate that exercise reduced anxiety-like behaviors and liver fibrosis markers, suggesting that exercise may offer therapeutic benefits by enhancing brain-derived neurotrophic factor (BDNF) levels and decreasing neuronal nitric oxide synthase (nNOS) activity, particularly in the hippocampus.
We examine whether one-to-one lifestyle counseling for non-insulin-treated diabetic outpatients by a Certified Expert Nurse (CEN) can improve patients' health outcomes. Participants were randomly assigned to a 1-year lifestyle intervention (n=67) or to a usual care group (n=67). Main outcome measures were changes from baseline in: HbA(1C) and score of health related quality of life scales (SF-36 and Problem Areas in Diabetes Scale).
View Article and Find Full Text PDFWe previously demonstrated that tumor necrosis factor (TNF)-alpha stimulated the production of activation protein (AP)-1, a transcriptional factor, in mouse osteoblastic MC3T3-E1 cells. Recent studies have shown the importance of ceramide and its metabolites as signal molecules for TNF-alpha-induced gene expression in several cell types. Therefore, our interest was to investigate whether sphingosine metabolites are involved in TNF-alpha-induced signaling in MC3T3-E1 cells.
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