Electron-beam induced terahertz radiation from graded metallic grating.

We have numerically analyzed, based on a simplified particle-in-cell finite-difference time-domain (PIC-FDTD) method, an electron-beam (e-beam) induced terahertz (THz) radiation from metallic grating structures with graded depths (graded grating). Upon exciting with e-beam, directional THz radiations with wide-band spectrum containing several sharp peaks are obtained only from the one of the edge of the grating, which cannot be expected from the conventional theory of Smith-Purcell radiation. It was clarified that each modes originate from different locations on the graded grating reflecting different dispersion characteristics of spoof surface plasmon polariton (spoof SPP) at each locations, and they can propagate toward only the shallower groove as a surface wave due to the cutoff at each locations, and all of these modes eventually emitted from the one of the edge of the graded grating.

Total palliative care for a patient with multiple cerebral infarctions that occurred repeatedly in association with gastric cancer (Trousseau's syndrome).

Objective: Malignancy-related thromboembolism, also referred to as Trousseau's syndrome, can present as acute cerebral infarction, nonbacterial thrombotic endocarditis (NBTE), and migratory thrombophlebitis. Therefore, many physical, neurological, and psychological symptoms associated with Trousseau's syndrome may occur in the clinical course.

Method: To illustrate this, we report a case of a male patient in his 50s with carcinomatous peritonitis caused by gastric cancer, with multiple cerebral infractions that developed during disease progression.

Retroperitoneal solitary fibrous tumor-induced hypoglycemia associated with high molecular weight insulin-like growth factor II.

A man, aged 65 years, presented with frequent episodes of hypoglycemia and unconsciousness. Hypoglycemia was accompanied by undetectable serum insulin and C-peptide levels and a high serum insulin-like growth factor (IGF)-II level. He was found to have a retroperitoneal solitary fibrous tumor.

[Complete remission of hepatic metastasis of gastric cancer with CPT-11].

We treated hepatic metastasis of gastric cancer with CPT-11 therapy and obtained complete remission of the hepatic tumor that has been maintained for than 2 years postoperatively. The patient was a 71-year-old man with a history of angina pectoris. In 1988, gastric cancer was diagnosed, and he underwent distal gastrectomy at another hospital.

Optimization of a coagulation factor VIIa inhibitor found in factor Xa inhibitor library.

An inhibitor of the complex of factor VIIa and tissue factor (fVIIa/TF), 2-substituted-4-amidinophenylpyruvic acid 1a, was structurally modified with the aim of increasing its potency and selectivity. The lead compound 1a was originally found in our factor Xa (fXa) inhibitor library on the basis of structural similarity of the primary binding sites of fVIIa and fXa. The design was based on computational docking studies using the extracted active site of fVIIa.