Environmental and physical factors predisposing middle-aged and older Japanese adults to falls and fall-related fractures in the home.

Aim: To identify environmental and physical factors that predispose middle-aged and older Japanese adults to falls and fall-related fractures in the home.

Methods: A cross-sectional survey was carried out in 2014. Self-administered questionnaires were distributed to 15 000 community-dwelling adults in Japan.

[Concomitant intracerebral hemorrhage and cerebral infarction in moyamoya disease: a case report].

We encountered a case of moyamoya disease which exhibited intracerebral hemorrhage with intraventricular hemorrhage followed by cerebral infarction in a short time. A 39-year-old female presenting with sudden onset disturbance of consciousness was admitted to our hospital. Radiological investigation on admission revealed intracerebral hemorrhage in the left temporal lobe and intraventricular hemorrhage due to moyamoya disease.

How does water diffusion in human white matter change following ischemic stroke?

Purpose: Temporal evolution of the water apparent diffusion coefficients (ADC) parallel (ADC parallel) and perpendicular (ADC perpendicular) to the human white matter tract following ischemia has not been investigated systematically. We attempted to quantify the evolution of ADC parallel and ADC perpendicular and examine whether it can be interpreted by a model of ischemic edema.

Methods: We retrospectively selected 53 patients with ischemic lesions involving the posterior limb of the internal capsule (PLIC) and placed regions of interest in the right and left PLIC on ADC maps.

[Case of enlargement of an intradiploic epidermoid cyst by a head contusion].

We report a case of enlargement of a intradiploic epidermoid cyst following head trauma in a 19-year-old man. The patient had a swelling on the right side of his forehead from the time of his birth. He sustained a bruise in this region when he was 15 years old, following which the swelling gradually enlarged.

Subarachnoid hemorrhage caused by rupture of a distal anterior inferior cerebellar artery aneurysm--three case reports.

Three female patients, two under 35 years old, presented with ruptured aneurysms of the distal anterior inferior cerebellar artery (AICA) manifesting as subarachnoid hemorrhage. The first patient had a ruptured saccular aneurysm of the meatal loop of AICA, which was treated by direct neck clipping. The second patient had a ruptured aneurysmal lesion that arose from a microvascular anomaly of the dorsolateral portion of the AICA, which was successfully treated by trapping.

[Case report of lumbar discal cyst].

The authors describe a rare case of lumbar discal cyst which produced manifestations similar o lumbar disc herniation. A 33-year-old man, who had had a crick in the back 3 months previously, suffered from severe low back and right lower-extremity pain. The neurological examination showed the L5 radiculopathy through the positive straight leg-raising test, no motor weakness nor sensory disturbance with normal reflexes.

[A case of spontaneous dissection of the cervical carotid artery with pseudoaneurysm].

We experienced the case of a dissecting carotid artery presenting with a pulsatile neck mass. This 60-year-old man was admitted to our department due to a progressive, painful left neck mass. The lesion was diagnosed as a dissecting left internal carotid artery with the subsequent formation of a giant pseudoaneurysm.

[An autopsy case of Down's syndrome with moyamoya syndrome].

We reported an autopsy case of Down's syndrome with moyamoya syndrome. A 30-year-old male with Down's syndrome suffered from a cerebral infarction and died of brain herniation. Cerebral angiography showed vascular abnormalities that were the same as moyamoya disease.

[Nontraumatic arterial dissection of the anterior cerebral artery: six cases report].

Nontraumatic arterial dissection of the anterior cerebral artery (NAD-ACA) is a relatively rare disease entity, although case reports have recently been increased. We treated 6 patients suffering from NAD-ACA from January 1996 to December 2003, and the neuroradiological findings together with the clinical courses were reviewed. There were 3 males and 3 females with a mean age of 57.

[Hemangioblastoma of the optic nerve growing like a dumbbell through the optic canal: case report].

We report a case of optic nerve hemangioblastoma in a 29-year-old man without a family history of von Hippel-Lindau disease or the other organ symptoms. He had progressive loss of vision and proptosis with a dull pain in his right eye. Magnetic resonance image (MRI) showed a gadolinium (Gd) enhancing solid tumor involving the prechiasmal right optic nerve with intraorbital extension.

[A case of peripheral-type primitive neuroectodermal tumor arising in the dura mater at the frontal base].

A 7-year-old boy was admitted to our hospital because of headache and frequent vomiting. The patient was noted to have papilloedema and mild palsy of the right abducent nerve. Magnetic resonance image (MRI) revealed a large tumor in the frontal base with tumoral hemorrhage.

Non-traumatic recurrent dissection and its spontaneous repair in the circle of Willis: report of two autopsy cases.

Post-mortem examinations of the circle of Willis in two cases of subarachnoid hemorrhage disclosed a wide spectrum of vasculopathy ranging from a minimal tear between the intima and media, and between the media and adventitia, to complete transmural disruption leading to the formation of pseudoaneurysms. The presence of coexistence of the focal lesions with complete replacement of the entire arterial wall with thick fibrous connective tissues and the vasculopathy was suggestive of the spontaneous repair of recurrent non-traumatic dissection of intracranial arteries. The patients were 58-year-old and 43-year-old females.

Which concentration of the inhibitor should be used to predict in vivo drug interactions from in vitro data?

When the metabolism of a drug is competitively or noncompetitively inhibited by another drug, the degree of in vivo interaction can be evaluated from the [I]u/Ki ratio, where [I]u is the unbound concentration around the enzyme and Ki is the inhibition constant of the inhibitor. In the present study, we evaluated the metabolic inhibition potential of drugs known to be inhibitors or substrates of cytochrome P450 by estimating their [I]u/Ki ratio using literature data. The maximum concentration of the inhibitor in the circulating blood ([I]max), its maximum unbound concentration in the circulating blood ([I]max,u), and its maximum unbound concentration at the inlet to the liver ([I]in,max,u) were used as [I]u, and the results were compared with each other.