Inhibition of experimental choroidal neovascularization by irsogladine, an anti-gastric ulcer agent.

Purpose: To determine whether irsogladine inhibits experimental choroidal neovascularization (CNV) induced by laser photocoagulation in pigmented rats.

Methods: Focal laser photocoagulation (argon green 50 mW, 0.04 s, 200 microm) was applied to the retinochoroid of normal Brown Norway rats.

Natural course of experimental choroidal neovascularization: three-dimensional study with corrosion cast and scanning electron microscope.

Objectives: The details of the morphological features of choroidal neovascularization (CNV) remain unclear. The purpose of this study was to establish a CNV rat model and study the natural course of CNV using vascular casts and a scanning electron microscope (SEM).

Methods: Focal laser photocoagulation (argon green 50 mW, 0.