Publications by authors named "Akiko Kitayama"
Article Synopsis
- The demand for metals like copper, lead, and zinc has led to increased interest in deep-sea mining, particularly for seafloor hydrothermal sulfide deposits, yet the environmental impacts are still largely unknown.
- This study utilized a bioassay with the marine cyanobacterium Cyanobium sp. NIES-981 to test the toxicity of sulfide core samples from the Izena Hole, finding that high levels of zinc and lead significantly inhibited the organism's delayed fluorescence.
- The research supports the effectiveness of the delayed fluorescence bioassay as a rapid and efficient method for assessing toxicity in deep-sea mining operations compared to traditional testing methods.
In vitro and in vivo antibacterial activities of CS-023 (RO4908463), a novel parenteral carbapenem.
Antimicrob Agents Chemother
August 2005
CS-023 (RO4908463, formerly R-115685) is a novel 1beta-methylcarbapenem with 5-substituted pyrrolidin-3-ylthio groups, including an amidine moiety at the C-2 position. Its antibacterial activity was tested against 1,214 clinical isolates of 32 species and was compared with those of imipenem, meropenem, ceftazidime, ceftriaxone, ampicillin, amikacin, and levofloxacin. CS-023 exhibited a broad spectrum of activity against gram-positive and -negative aerobes and anaerobes, including methicillin-resistant Staphylococcus aureus (MRSA), methicillin-resistant Staphylococcus epidermidis, penicillin-resistant Streptococcus pneumoniae (PRSP), beta-lactamase-negative ampicillin-resistant Haemophilus influenzae, and Pseudomonas aeruginosa.
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