Publications by authors named "Akiko Kanaya"
Article Synopsis
- Overdose and underdose prescription errors can lead to severe health risks, highlighting the need for effective detection and prevention methods.
- A study utilized a one-class support vector machine (OCSVM) to analyze prescription data from Kyushu University Hospital to identify these dosing errors based on patient age, weight, and dosage.
- The OCSVM model proved highly effective, detecting 87.1% of clinical errors and outperforming other machine learning algorithms in identifying both synthetic overdose and underdose prescriptions.
For many of the novel antiepileptics, immunoassays, used for routine therapeutic drug monitoring (TDM), cannot be used. We could monitor eight novel antiepileptics using an LC/MS method since July 2017. The purpose of this study was to evaluate the significant changes associated with the transition from outsourcing to in-hospital monitoring of novel antiepileptics.
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- * The patient underwent hemodialysis and was initially treated with high-dose steroids and plasma exchange, leading to improvement, but her antibody levels later increased again.
- * Eventually, she was treated with the immunosuppressive drug mizoribine (MZR) alongside steroid therapy, resulting in stable antibody levels and improved blood counts, marking the first documented use of MZR for this specific case in dialysis patients.
Aim: The effect of tonsillectomy on IgA nephropathy remains controversial. The aim of this study was to compare the effect of tonsillectomy on the outcome, end stage kidney disease (ESKD) and all-cause death in IgA nephropathy patients who did and did not undergo tonsillectomy.
Methods: All basic data were retrospectively gathered from patients who had undergone renal biopsies at two Japanese clinical centres.
Background: Differences in error rates between pharmacists and nurses in terms of drug confirmation have not been studied. The purpose of this study was to analyze differences in error rates between pharmacists and nurses from the viewpoint of error categories, and to clarify differences in recognition regarding drug name similarity.
Methods: In this study, preparation errors and incidents were classified into three categories (drug strength errors, drug name errors, and drug count errors) to investigate the influence of error categories on pharmacists and nurses.
Background: There are many reports regarding various medical institutions' attempts at incident prevention, but the relationship between incident types and impact on patients in drug name errors has not been studied. Therefore, we analyzed the relationship between them, while also assessing the relationship between preparation and inspection errors. Furthermore, the present study aimed to clarify the incident types that lead to severe patient damage.
View Article and Find Full Text PDFBackground: Although TINU syndrome is characterized by idiopathic TIN with bilateral anterior uveitis, few reports have provided a comprehensive summary of the features of this disorder. Previous reports have suggested that many Japanese patients had HLA-A2 and -A24 (7), but there is no evidence.
Case Report: A 44-year-old female was referred to our hospital due to renal dysfunction in March 2012.
The effects of tiotropium, an inhaled long-acting anti-cholinergic agent, on lung function were investigated in obstructed severe asthmatics with and without emphysematous changes despite maximal recommended treatments with high-dose of inhaled glucocorticoids and inhaled long-acting β(2)-agonists. We conducted a double-blind, placebo-controlled study of an inhaled single-dose of tiotropium in 18 asthmatics with emphysema and 18 without emphysema in a crossover manner. The primary efficacy outcome was the relative change in forced expiratory volume in 1 s (FEV(1)) from baseline to 60 min, and the secondary outcome was a relative change in FEV(1) from baseline to 12 h.
View Article and Find Full Text PDFBackground: Patients with severe asthma require multiple therapies to improve lung function and reduce symptoms. The use of long-acting inhaled beta(2)-agonists plus theophylline in addition to high doses of inhaled corticosteroids (ICSs) for the treatment of severe asthma has not been extensively studied.
Objective: The purpose of this study was to investigate the efficacy and safety of salmeterol combined with high-dose ICSs plus theophylline in severe asthma.