Publications by authors named "Akiko Ichihara"
Article Synopsis
- Immune checkpoint inhibitors, such as pembrolizumab, have shown effectiveness in treating metastatic colorectal cancer (CRC) with microsatellite instability-high (MSI-H), though liver metastasis often indicates resistance to these therapies.
- A case study focuses on a 23-year-old man with MSI-H colorectal liver metastasis who achieved a complete pathological response after receiving pembrolizumab following chemotherapy.
- Pathological analyses revealed high PD-L1 expression in both the primary tumor and regional lymph nodes, suggesting that examining lymph nodes could help predict responses to anti-PD-1/PD-L1 therapies in cancer treatment.
Background: Oxaliplatin (OX)-based chemotherapy induces sinusoidal obstruction syndrome (SOS) in the nontumorous liver parenchyma, which can increase the risk of liver resection due to colorectal liver metastasis (CRLM). The extracellular volume (ECV) calculated from contrast-enhanced computed tomography (CT) has been reported to reflect the morphological change of hepatic fibrosis. The present retrospective study aimed to evaluate the ECV fraction as a predictive factor for OX-induced SOS.
View Article and Find Full Text PDFBackground: Adult cases of retroperitoneal isolated enteric duplication cyst (IEDC) are rare, with only 17 case reports in the relevant literature. We herein present a case, which was characterized by changes in intra-cystic density on computed tomography (CT), which was safely resected by laparoscopic surgery.
Case Presentation: The patient was a 60-year-old male who received abdominal CT to investigate the cause of increased serum CA19-9 levels.
Objectives: This study aimed to clarify the factors of successful inter-agency collaboration that affect multidisciplinary workers' abilities to identify child maltreatment. A questionnaire-based survey was conducted; the contents of the questionnaire included the Collaboration Evaluation Scale we developed and the workers' abilities to identify child maltreatment. In total, 277 individuals from various agencies in Japan participated in this study.
View Article and Find Full Text PDFA rare case of rectal cancer with perianal metastasis: a case report.
World J Surg Oncol
August 2019
Background: Cancer metastasis from colon cancer to an anal fistula is very rare. We herein reported a rare case in which local excision was performed for metastatic anal fistula cancer originating from rectal cancer.
Case Presentation: A 68-year-old man was referred to our institution with a diagnosis of rectal cancer.