Effects of lowering the proposed top-concentration limit in an in vitro chromosomal aberration test on assay sensitivity and on the reduction of the number of false positives.

For the in vitro chromosomal aberration (CA) test, the proposed top-concentration limit will be reduced to '10mM or 2mg/mL' (whichever is lower) in the draft revised OECD (r-OECD) test guideline (TG) 473, down from '10mM or 5mg/mL' in the current OECD TG, which was adopted in 1997 (1997-OECD). It was previously reduced to 1mM or 0.5mg/mL in the International Conference of Harmonization (ICH) S2 (R1) guideline for pharmaceuticals.

CELLPEDIA: a repository for human cell information for cell studies and differentiation analyses.

CELLPEDIA is a repository database for current knowledge about human cells. It contains various types of information, such as cell morphologies, gene expression and literature references. The major role of CELLPEDIA is to provide a digital dictionary of human cells for the biomedical field, including support for the characterization of artificially generated cells in regenerative medicine.

[Case of Marfan's syndrome with anterior sacral meningocele along with recurring bacterial meningitis].

We reported a 46-year-old woman with Marfan's syndrome exhibiting an incomplete Currarino triad and recurrent bacterial meningitis which recurred three times in about six months. An anterior sacral meningocele (ASM) was noted in a lumbar MRI, and multiple bone defects in the sacrum were noted in 3D-CT. Surgical approach to prevent the recurrence of infection was limited to plasty for the meningocele, but no meningitis has been observed for two years.