Size-dependent guest-memory switching of the flexible and robust adsorption characteristics of layered metal-organic frameworks.

Flexible-robust metal-organic frameworks (MOFs), which exhibit unique hybrid nature comprising both flexible and rigid framework characteristics, exhibit high potential for hydrocarbon separations. However, no clear guidelines have been established to regulate their hybrid characteristics owing to limited understanding of their adsorption mechanism. This study investigates the effects of the particle size of a flexible-robust MOF on its adsorption and structural transition behaviors.

Early impairment in a water-finding test in a longitudinal study of the Tg2576 mouse model of Alzheimer's disease.

Behavioral assessments of mouse models of neurodegenerative disorders are useful for investigating the molecular basis of the pathologies of the diseases. Here, we investigated the utility of a water-finding test using a video tracking system as a tool for evaluating cognitive deficits in Alzheimer's disease model mice. Transgenic mice expressing mutant amyloid precursor protein that incorporated the Swedish mutation (Tg2576 mice) were tested for behavioral alterations at 3, 5, 6, or 10 months of age.