Publications by authors named "Akiko Ezuka"
Article Synopsis
- Aberrant crypt foci (ACF) are potential indicators for colorectal cancer (CRC) and were studied to understand their association with factors like lifestyle, medications, and health conditions.
- A study involving 902 subjects showed that older age, smoking, and insulin use significantly increased the prevalence of ACF, which are precursors to CRC.
- The research concluded that ACF can aid in assessing CRC risk, and insulin may contribute to increased cell proliferation in the colon, possibly leading to CRC development.
Article Synopsis
- Small bowel angioectasia is a leading cause of obscure gastrointestinal bleeding, and while endoscopic treatment can be effective, rebleeding rates remain high.
- A study involving 68 patients showed a 33.8% overall rebleeding rate after a median follow-up of 30.5 months, with endoscopic treatment somewhat reducing rebleeding risk.
- The presence of multiple lesions (three or more) was identified as a significant predictor for rebleeding, indicating that these patients require careful monitoring and may benefit from repeated endoscopic procedures.
Background: To develop appropriate management strategies for patients who take low-dose aspirin, it is important to identify the risk factors for GI injury. However, few studies have described the risk factors for small-bowel injury in these patients.
Objective: To investigate factors influencing the risk of small-bowel mucosal breaks in individuals taking continuous low-dose aspirin.
Obscure gastrointestinal bleeding (OGIB) is one of the common complications in patients with chronic kidney disease (CKD), especially those who are on maintenance hemodialysis (HD). However, little is known about the characteristics of the small-bowel lesions in these patients, or of the factors that could predict the presence of such lesions. Therefore we enrolled a total of 42 CKD patients (including 19 HD patients and 23 non-HD patients), and compared the incidence of the small-bowel lesions among two groups.
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- * After reducing her prednisolone dosage from 30 mg to 0 mg, her abdominal symptoms improved significantly, leading to normal bowel movements.
- * The findings suggest a potential link between prednisolone and the development of pneumatosis cystoides intestinalis, indicating that the condition might be influenced by the steroid's dosage.
Aim: To identify the predictive factors for the presence of small bowel lesions in patients with obscure gastrointestinal bleeding (OGIB).
Methods: A total of 242 patients with OGIB (overt 149: occult 93) were retrospectively included in the present study. Capsule endoscopy (CE) was carried out to investigate the small bowel, and detected lesions were classified according to the P0-P2 system.
Background: Colorectal cancer (CRC) is one of the most commonly occurring neoplasms and a leading cause of cancer death worldwide, and new preventive strategies are needed to lower the burden of this disease. Eicosapentaenoic acid (EPA), the omega-3 polyunsaturated fatty acid that is widely used in the treatment of hyperlipidemia and prevention of cardiovascular disease, has recently been suggested to have a suppressive effect on tumorigenesis and cancer cell growth. In CRC chemoprevention trials, in general, the incidence of polyps or of the cancer itself is set as the study endpoint.
View Article and Find Full Text PDFBackground: Colorectal cancer is one of the major neoplasms and a leading cause of cancer death worldwide, and new preventive strategies are needed to lower the burden of this disease. Metformin, a biguanide, which is widely used for treating diabetes mellitus, has recently been suggestive to have a suppressive effect on tumorigenesis and cancer cell growth. In a previous study conducted in non-diabetic subjects, we showed that oral short-term low-dose metformin suppressed the development of colorectal aberrant crypt foci (ACF).
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