The TAT Protein Transduction Domain as an Intra-Articular Drug Delivery Technology.

Objective: Intra-articular drug delivery holds great promise for the treatment of joint diseases such as osteoarthritis. The objective of this study was to evaluate the TAT peptide transduction domain (TAT-PTD) as a potential intra-articular drug delivery technology for synovial joints.

Design: Experiments examined the ability of TAT conjugates to associate with primary chondrocytes and alter cellular function both and .